{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:40:44Z","timestamp":1791855644094,"version":"4.3.4"},"reference-count":6,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7154,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We are reporting on two Lehrerleut Hutterite sisters who have a syndrome of 1) congenital shortness with mild spondylorhizomelic dwarfism; 2) later failure to thrive, ie deceleration of weight gain presumably due to CNS\u2010based severe feeding problems; 3) a CNS defect, probably developmental (not biochemical) with normal prenatal brain growth but later deceleration from 50th to 2nd centile associated with severe mental retardation and decorticate disturbances of neurologic function; and 4) possible renal involvement with terminal nephrotic syndrome.<\/jats:p><jats:p>This seems to be a previously undescribed pleiotropic autosomal recessive trait.<\/jats:p>","DOI":"10.1002\/ajmg.1320220310","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T20:00:52Z","timestamp":1118520052000},"page":"521-529","source":"Crossref","is-referenced-by-count":16,"title":["Hutterite cerebro\u2010osteo\u2010nephrodysplasia: Autosomal recessive trait in a Lehrerleut Hutterite family from Montana"],"prefix":"10.1002","volume":"22","author":[{"given":"John M.","family":"Opitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Brian","family":"Lowry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Mary","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"64","volume-title":"An Introduction to Population Genetics Theory","author":"Crow JF","year":"1970"},{"key":"e_1_2_1_3_1","first-page":"426","article-title":"A method for calculating the inbreeding coefficient","volume":"14","author":"Kudo A","year":"1962","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320220312"},{"key":"e_1_2_1_5_1","first-page":"189","article-title":"Some genetic programs to supplement self\u2010instruction in FORTRAN","volume":"19","author":"MacCluer JW","year":"1967","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_6_1","first-page":"8","volume-title":"The Mathematics of Heredity","author":"Mal\u00e9cot G","year":"1969"},{"key":"e_1_2_1_7_1","first-page":"174","volume-title":"Evolution and the Genetics of Population. Volume. 2 The Theory of Gene Frequencies","author":"Wright S","year":"1969"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320220310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320220310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T20:16:10Z","timestamp":1697832970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320220310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,11]]}},"alternative-id":["10.1002\/ajmg.1320220310"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320220310","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,11]]}}}