{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:17:42Z","timestamp":1773325062038,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7124,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1985,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present data from the Latin American Collaborative Study of Congenital Malformations (ECLAMC) on prevalence rates and etiologic factor associations in neural tube defects. Two series of data are analyzed: the A series, including 740, 139 consecutive infants born in the 1967\u20131979 period suitable for secular trend analysis and case\u2010control study of risk factors; and the B series, including 255, 834 consecutive stillborn and liveborn infants of the 1980\u20131982 period suitable for prevalence rate analysis. Anencephaly was registered in 6.0\/10,000 births, spina bifida aperta in 6.2\/10,000 births, and cephalocele in 2.4\/10,000 births. A stable secular trend was observed for the frequency of all three neural tube defect types. Spina bifida was more frequent in Chile than in the rest of South America. No differences in prevalence rates were seen between tropical and non tropical areas. Parental consanguinity and environmental prenatal factors including maternal illnesses, drug intake, and radiation exposure were found in association with anencephaly and spina bifida.<\/jats:p>","DOI":"10.1002\/ajmg.1320220406","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T20:01:11Z","timestamp":1118520071000},"page":"695-702","source":"Crossref","is-referenced-by-count":22,"title":["Epidemiology of neural tube defects in South America"],"prefix":"10.1002","volume":"22","author":[{"given":"Eduardo E.","family":"Castilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u011bda M.","family":"Orioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"494","article-title":"Estudio latinoamericano sobre malformaciones cong\u00e9nitas","volume":"76","author":"Castilla E","year":"1974","journal-title":"Bol Sanit Panam"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)92391-4"},{"key":"e_1_2_1_4_1","volume-title":"Epidemiology of Anencephaly and Spina Bifida","author":"Elwood JM","year":"1980"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(83)91198-5"},{"key":"e_1_2_1_6_1","first-page":"13","article-title":"Geographical variations in the mortality attributed to spina bifida and other congenital malformations","volume":"17","author":"Hewith D","year":"1973","journal-title":"Br J Prev Soc Med"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197602122940704"},{"key":"e_1_2_1_8_1","volume-title":"International Classification of Diseases, Eighth Revision","year":"1965"},{"key":"e_1_2_1_9_1","volume-title":"1982 Annual Report","year":"1983"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113335"},{"key":"e_1_2_1_11_1","first-page":"980","article-title":"Etiologic heterogeneity of neural tube defects: II. Clues from family studies","volume":"34","author":"Khoury MJ","year":"1982","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320160410"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-6405.1983.tb00392.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320100103"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1542\/peds.65.3.636","article-title":"The puzzling epidemiology of neural tube defects","volume":"65","author":"Mortimer EA","year":"1980","journal-title":"Pediatrics"},{"key":"e_1_2_1_16_1","first-page":"1109","article-title":"Incidence of neural tube defects in liveborn and stillborn infants in British Columbia over a 10\u2010year period","volume":"129","author":"Sadovnick AD","year":"1983","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92654-5"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90886-7"},{"key":"e_1_2_1_19_1","first-page":"1","article-title":"Congenital malformations: A report of a series of consecutive births in 24 centers","volume":"34","author":"Stevenson AC","year":"1966","journal-title":"Bull WHO"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320220406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320220406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T16:34:42Z","timestamp":1697819682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320220406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,12]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,12]]}},"alternative-id":["10.1002\/ajmg.1320220406"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320220406","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,12]]}}}