{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T16:38:03Z","timestamp":1706287083634},"reference-count":18,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7093,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Not few reports of sex chromosome aneuploidy in association with the fragile site at Xq28 have appeared, suggesting other factors than pure coincidence. In the present report lymphocyte cultures from 23 obligate and 45 potential carriers have been examined cytogenetically. As expected, an increase in sex chromosome aneuploidy with increasing age was observed. However, it seemed that the increase of hyperdiploid cells was far in excess of the expected, and a difference between obligate and potentialcarriers was apparently also present. Hence, a disposition to non\u2010disjunction of the fragile X chromosome is suggested.<\/jats:p>","DOI":"10.1002\/ajmg.1320230146","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T20:02:23Z","timestamp":1118520143000},"page":"537-544","source":"Crossref","is-referenced-by-count":13,"title":["Sex chromosome aneuploidy in fragile X carriers"],"prefix":"10.1002","volume":"23","author":[{"given":"Karen Br\u00f8ndum","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"AbruzzoMA MayerM JacobsPA(in press):Aging and aneuploidy. Evidence for the preferential involvement of the inactive X chromosome. Cytogen Cell Genet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270565"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00303019"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1984.tb01086.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130842"},{"key":"e_1_2_1_7_1","first-page":"234","article-title":"FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition","volume":"33","author":"Glover TW","year":"1981","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_1","first-page":"514","article-title":"Unsuspected encounters in cytogenetics: Repeated abortions and parental sex chromosome mosaicism may indicate risk of non\u2010disjunction","volume":"34","year":"1982","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1984.tb00786.x"},{"key":"e_1_2_1_10_1","first-page":"237","article-title":"X chromosome hyperploidy in couples with multiple spontaneous abortions","volume":"63","author":"Holzgreve W","year":"1984","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/1911178a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.22.1.32"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"234A","DOI":"10.1111\/j.1399-0004.1983.tb01973.x","article-title":"Marker X associated mental retardation. Observations of the X chromosome","volume":"23","author":"K\u00e4hkonen M","year":"1983","journal-title":"Clin Genet"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00279401"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320210413"},{"key":"e_1_2_1_16_1","first-page":"117A","article-title":"Sex chromosome mosaicism in couples with repeated fetal loss","volume":"33","author":"Reinisch LC","year":"1981","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.18.5.374"},{"key":"e_1_2_1_18_1","first-page":"549","article-title":"Cytogenetic studies in loo couples with recurrent spontaneous abortions","volume":"32","author":"Ward BE","year":"1980","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_19_1","first-page":"285","article-title":"The Xq27 fragile site and 47 XXY","volume":"94","author":"Wilmot PL","year":"1980","journal-title":"Am J Hum Genet"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320230146","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320230146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T15:50:54Z","timestamp":1706284254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320230146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":18,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1002\/ajmg.1320230146"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320230146","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}