{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:48:05Z","timestamp":1779122885722,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T00:00:00Z","timestamp":1118016000000},"content-version":"vor","delay-in-days":6976,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Five families with concurrent von Willebrand's disease (VWD) and classic hemophilia (hemophilia A) are described. Three were ascertained through women undergoing hemophilia carrier testing, one through an obligate carrier who also has VWD, and one through the affected father of a hemophiliac. The VWD probands exhibited Type I VWD with reduced Factor VIII\u2010related antigen (VIIIR: Ag) and\/or von Willebrand factor on more than one occasion, normal VIIIR: Ag on crossed immunoelectrophoresis, and mild symptoms. No male had both disorders, but two obligate hemophilia carriers alos had VWD. Neither was detectable as a carrier by discriminant analysis. Four possible carriers of hemophilia had VWD and would also be classified as noncarriers statistically. These findings suggest that the presence of VWD may invalidate hemophilia carrier testing by conventional methods. The independent entry into the family of the two genes by mating of a hemophilia carrier and a VWD male is documented in two cases and probable in two. The observed frequency of such matings supports the hypothesis that VWD is a common disorder.<\/jats:p>","DOI":"10.1002\/ajmg.1320240110","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T20:03:51Z","timestamp":1118520231000},"page":"83-94","source":"Crossref","is-referenced-by-count":11,"title":["Concurrence of von Willebrand's disease and hemophilia A: Implications for carrier detection and prevalence"],"prefix":"10.1002","volume":"24","author":[{"given":"Connie H.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret W.","family":"Hilgartner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Bussel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis M.","family":"Aledort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1182\/blood.V56.4.712.712","article-title":"Serial studies in von Willebrand's disease: variability versus \u201cvariants\u201d","volume":"56","author":"Abildgaard CF","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_3_1","first-page":"203","article-title":"Von Willebrand's disease","volume":"4","author":"Barrow EM","year":"1964","journal-title":"Progr Hematol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1974.54.1.23"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.37.9.1035"},{"issue":"40","key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1600-0609.1984.tb02596.x","article-title":"Von Willebrand's disease: state of the art","volume":"33","author":"Bowie EJW","year":"1984","journal-title":"Scand J Haematol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(76)90248-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1182\/blood.V49.4.607.607","article-title":"Carriers with excessively low Factor VIII procoagulant activity (VIII AHF): a study of two unrelated families with mild hemophilia A","volume":"49","author":"Eyster EM","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1978.tb02478.x"},{"key":"e_1_2_1_10_1","first-page":"424","article-title":"Occurrence of two hemorrhagic disorders with antihemophilic factor (AHF) deficiency in the same family: classical hemophilia and von Willebrand's disease","volume":"61","author":"Geiger MT","year":"1963","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0308-2261(21)00066-7","article-title":"Genotype assignment (carrier detection) in the hemophilias","volume":"8","author":"Graham JB","year":"1979","journal-title":"Clin Haematol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb53335.x"},{"key":"e_1_2_1_13_1","first-page":"482","article-title":"The phenotypic range of hemophilia A carriers","volume":"28","author":"Graham JB","year":"1976","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1972.tb15938.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1055\/s-0038-1665305","article-title":"Factor VIII levels and blood group antigens","volume":"50","author":"McCallum CJ","year":"1983","journal-title":"Thromb Haemostas"},{"key":"e_1_2_1_16_1","first-page":"29","volume-title":"Hemophilia in Children and Adults","author":"Miller CH","year":"1982"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V54.1.117.117"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1182\/blood.V54.1.137.137","article-title":"Genetics of classic von Willebrand's disease. 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