{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:17:21Z","timestamp":1756995441476},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T00:00:00Z","timestamp":1118016000000},"content-version":"vor","delay-in-days":6976,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Of 40,000 initial amniotic fluid samples, 0.7% had an alphafetoprotein (AFP) level \u2a7e +3 standard deviations above the mean. The risk of an open neural tube defect (NTD) or other serious fetal abnormality was 61% when AFP levels measured \u2a7e +3 and 87% for levels \u2a7e +5 standard deviations. If the acetylcholinesterase (AChE) was positive, this risk was 84% and 95% for AFP levels of \u2a7e +3 and \u2a7e +5 SD, respectively, and 29% and 62% for the same levels if the AChE was negative. If the second amniocentesis AFP was also \u2a7e +3, the risk of an abnormality was 96%. In this series, there were 93 open neural tube defects, and all were identified. The true false\u2010positive rate was 1 per 13,000 of the cases screened. The recurrence risk for an NTD was 1.8%, and the incidence of NTDs in women having amniocentesis only for maternal age was 1.5 per 1,000.<\/jats:p>","DOI":"10.1002\/ajmg.1320240118","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T20:03:51Z","timestamp":1118520231000},"page":"143-149","source":"Crossref","is-referenced-by-count":14,"title":["Routine amniotic fluid alphafetoprotein assay: Experience with 40,000 pregnancies"],"prefix":"10.1002","volume":"24","author":[{"given":"Barbara F.","family":"Crandall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myles","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"651","article-title":"Amniotic fluid AFP measurment in antenatal diagnosis of anencephaly and open spina bifida in early pregnancy","author":"2nd Report of the UK Collaborative Study on AFP in relation to NTDs","year":"1979","journal-title":"Lancet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91145-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320120314"},{"key":"e_1_2_1_5_1","first-page":"524","article-title":"Maternal serum AFP screening for the detection of NTDs","volume":"138","author":"Crandall BF","year":"1983","journal-title":"West J Med"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1001\/jama.1980.03310240023017","article-title":"Prenatal detection of neural tube defects VI. Experience with 20,000 pregnancies","volume":"244","author":"Milunksy A","year":"1980","journal-title":"JAMA"},{"key":"e_1_2_1_7_1","first-page":"684","article-title":"Amniotic fluid acetylcholinesterase as a possible diagnostic test for NTD in early pregnancy","author":"Smith AD","year":"1979","journal-title":"Lancet"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320240118","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320240118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T18:20:10Z","timestamp":1697826010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320240118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,5]]}},"alternative-id":["10.1002\/ajmg.1320240118"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320240118","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,5]]}}}