{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:21:58Z","timestamp":1782375718142,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":6912,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An increased prevalence of mitral\u2010valve prolapse occurs in several connective tissue dysplasias, including Marfan syndrome, Ehlers\u2010Danlos syndrome, and pseudoxanthoma elasticum. We evaluated 57 patients diagnosed as having the Stickler syndrome for mitral\u2010valve prolapse by ausculation and two\u2010dimensional echocardiography. The diagnosis was made on the basis of craniofacial and musculoskeletal abnormalities, sensorineural hearing loss, eye defects, and a family history of Stickler syndrome. Twenty\u2010six patients (45.6%) had mitral\u2010valve prolapse, including 11 of 22 females (50.0%) and 15 of 35 males (42.9%). The age range of our study population was 4 to 60 years. Prevalence of mitral\u2010valve prolapse did not increase with age. Nine patients (34.6% of those with mitral\u2010valve prolapse) had the click\u2010murmur syndrome; only one of them was symptomatic.<\/jats:p><jats:p>Because of the growing list of complications associated with mitral\u2010valve prolapse, all patients with Stickler syndrome should be evaluated by auscultation, electrocardiogram, and echocardiography. Those with mitral\u2010valve prolapse should be advised to have periodic follow\u2010up and to instruct physicians caring for them of their need for antibiotic prophylaxis with certain surgical procedures.<\/jats:p>","DOI":"10.1002\/ajmg.1320240302","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T20:05:48Z","timestamp":1118520348000},"page":"387-392","source":"Crossref","is-referenced-by-count":63,"title":["Prevalence of mitral\u2010valve prolapse in the Stickler syndrome"],"prefix":"10.1002","volume":"24","author":[{"given":"Ruth M.","family":"Liberfarb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Goldblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"139A","article-title":"Prevention of bacterial endocarditis","volume":"56","author":"American Heart Association Committee on Prevention of Rheumatic Fever and Bacterial Endocarditis","year":"1977","journal-title":"Circulation"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(75)90906-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.52.4.651"},{"key":"e_1_2_1_5_1","first-page":"77","article-title":"Incidence of mitral valve prolapse in the asymptomatic normal","volume":"52","author":"Brown OR","year":"1975","journal-title":"Circulation"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.245.13.1357"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198209233071302"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.40.5.468"},{"key":"e_1_2_1_9_1","first-page":"345","article-title":"Collagen synthesis in floppy mitral valve","volume":"45","author":"Davies MJ","year":"1981","journal-title":"Br Heart J (Abstr)"},{"issue":"2","key":"e_1_2_1_10_1","first-page":"76","article-title":"The Stickler syndrome (hereditary arthroophthalmopathy)","volume":"11","author":"Herrmann J","year":"1975","journal-title":"BD:OAS"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198207223070406"},{"issue":"6","key":"e_1_2_1_12_1","first-page":"525","article-title":"The Wagner\u2010Stickler syndrome","volume":"18","author":"Liberfarb RM","year":"1982","journal-title":"BD:OAS"},{"issue":"5","key":"e_1_2_1_13_1","first-page":"145","article-title":"The Wagner\u2010Stickler syndrome\u2013A genetic study","volume":"15","author":"Liberfarb RM","year":"1979","journal-title":"BD:OAS"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80324-1"},{"key":"e_1_2_1_15_1","first-page":"1054","article-title":"Hypomastia and mitral\u2010valve prolapse. 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