{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:43:01Z","timestamp":1767703381107},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":6912,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Isolated, apparently nonsyndromic cleft palate (CP) is thought to be etiologically heterogeneous. The multifactorial threshold explanation for CP is postulated in most cases. Mendelian inheritance has been documented in 3 families. We report on three unrelated white families with 17 relatives in several generations affected with CP, including submucous CP and bifid\/absent uvula. We could find no evidence of a cleft syndrome. In one family, the pattern is consistent with autosomal dominant inheritance. In 2 families, the pattern is consistent with X\u2010linked recessive inheritance. The specific findings and their implications for family evaluation and genetic counseling are discussed.<\/jats:p>","DOI":"10.1002\/ajmg.1320240309","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T20:05:48Z","timestamp":1118520348000},"page":"465-473","source":"Crossref","is-referenced-by-count":21,"title":["Mendelian inheritance of isolated nonsyndromic cleft palate"],"prefix":"10.1002","volume":"24","author":[{"given":"Beverly R.","family":"Rollnick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia I.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"10","article-title":"Genetics and clefting","volume":"18","author":"Bixler D","year":"1981","journal-title":"Cleft Palate J"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.19.5.329"},{"key":"e_1_2_1_4_1","first-page":"325","volume-title":"Etiology of Cleft Lip and Cleft Palate","author":"Chung CS","year":"1980"},{"key":"e_1_2_1_5_1","first-page":"576","volume-title":"Principles and Practice of Medical Genetics","author":"Cohen MM","year":"1983"},{"key":"e_1_2_1_6_1","volume-title":"Inheritance of Harelip and Cleft Palate","author":"Fogh\u2010Andersen P","year":"1942"},{"key":"e_1_2_1_7_1","first-page":"336","article-title":"The genetics of cleft lip and cleft palate","volume":"22","author":"Fraser FC","year":"1970","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_1","first-page":"110","volume-title":"Syndromes of the Head and Neck","author":"Gorlin RJ","year":"1976"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00287053"},{"key":"e_1_2_1_10_1","volume-title":"SX\u2010linked cleft palate","author":"Lowry RB","year":"1971"},{"issue":"7","key":"e_1_2_1_10_2","first-page":"76","volume":"7","author":"The National Foundation\u2014March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00286901"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1981.tb01800.x"},{"key":"e_1_2_1_13_1","first-page":"476","article-title":"Isolated cleft palate: A genealogic study using codified genealogic questionnaire","volume":"7","author":"Tolarova M","year":"1970","journal-title":"Cleft Palate J"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.3.1.17"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320240309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320240309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T18:27:19Z","timestamp":1697826439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320240309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,7]]}},"alternative-id":["10.1002\/ajmg.1320240309"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320240309","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7]]}}}