{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:00:08Z","timestamp":1770429608335,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,4]],"date-time":"2005-06-04T00:00:00Z","timestamp":1117843200000},"content-version":"vor","delay-in-days":6790,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1986,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study is to determine whether couples receiving genetic counselling because of a child with a neural tube defect (NTD) are a selected group and therefore not representative of the general population with respect to sib risks for NTDs.<\/jats:p><jats:p>British Columbia (B.C.) provides an excellent opportunity to look at this for several reasons. Firstly, genetic counselling services are centralized. Secondly, there is virtually complete ascertainment of all infants with NTDs in the province. Thirdly, sib risks for NTDs in the general population have been derived previously [McBride, 1979] and, therefore, are available for comparison with the risks for sibships in the clinic populations.<\/jats:p><jats:p>In the present study, data were available on 398 sibships in which the index case had anencephaly and\/or spina bifida. In all instances, sib risks for the clinic populations did not differ significantly from those for the general population. In addition, congenital malformations other than NTDs did not occur among sibs of index cases more often than expected, based on provincial incidence data.<\/jats:p>","DOI":"10.1002\/ajmg.1320250320","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T20:08:47Z","timestamp":1118520527000},"page":"563-573","source":"Crossref","is-referenced-by-count":4,"title":["Risks to sibs of probands with neural tube defects: Data for clinic populations in British Columbia"],"prefix":"10.1002","volume":"25","author":[{"given":"B.","family":"Keena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"Sadovnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Baird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90697-3"},{"key":"e_1_2_1_3_1","volume-title":"Handicapped Children and Youth","author":"Baird PA","year":"1985"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a071318"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.10.3.209"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.1.14"},{"key":"e_1_2_1_7_1","first-page":"313","article-title":"Measuring morbidity in a population: The British Columbia Health Surveillance Registry","volume":"73","author":"Colls MH","year":"1982","journal-title":"Can J Public Health"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320050314"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.21.6.413"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.13.4.253"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.13.4.263"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.20.5.338"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6169.975"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91104-7"},{"key":"e_1_2_1_15_1","unstructured":"Health Surveillance Registry(1981): Annual Report. Province of British Columbia Ministry of Health Division of Vital Statistics. H.S.R. No. 6."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.21.1.73"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6105.72"},{"key":"e_1_2_1_18_1","first-page":"980","article-title":"Etiologic heterogeneity of neural tube defects. II. Clues from family studies","volume":"34","author":"Khoury MJ","year":"1982","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6083.361"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.18.4.322"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1984.tb01104.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320030409"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320160410"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)92217-9"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","unstructured":"PolandBJ MillerJR HarrisM LivingstonJ(1981):Spontaneous abortion. A study of 1 961 women and their conceptuses. Acta Obstet Gynecol Scand Supplement 102.","DOI":"10.3109\/00016348109155309"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90237-8"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420320305"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.18.4.245"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320150409"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320210103"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420170111"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320020102"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.5.338"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320250320","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320250320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T19:47:08Z","timestamp":1697831228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320250320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,11]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,11]]}},"alternative-id":["10.1002\/ajmg.1320250320"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320250320","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,11]]}}}