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Total craniorachischisis, anencephaly with cervical spina bifida, holoacrania, and thoracic spina bifida showed a greater female excess than that overall; the sex ratio for meroacrania was close to unity, while that for low spinal lesions, particularly those involving the sacrum, showed an extreme bias towards males. These findings are related to the mode of formation of the neural tube. Females seem prone to defects of neurulation and males to defects in canalisation. An explanation for these findings is suggested in possible sex differences in rate of early embryonic development.<\/jats:p>","DOI":"10.1002\/ajmg.1320260325","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:46:04Z","timestamp":1118544364000},"page":"699-707","source":"Crossref","is-referenced-by-count":92,"title":["Neural tube defects and sex ratios"],"prefix":"10.1002","volume":"26","author":[{"given":"Mary J.","family":"Seller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,4]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"9","article-title":"Sacrococcygeal developmental abnormalities 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