{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:20:37Z","timestamp":1790014837167,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,4]],"date-time":"2005-06-04T00:00:00Z","timestamp":1117843200000},"content-version":"vor","delay-in-days":6639,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Homocystinuria commonly affects the central nervous system (CNS), primarily as mental retardation, seizures, and stroke. Case reports have long suggested a predisposition to schizophrenia, but no careful study of predisposition to psychiatric illness has been performed. Accordingly, we evaluated 63 persons with homocystinuria due to cystathionine \u03b2\u2010synthase deficiency for psychiatric disturbance, intelligence, evidence of other CNS problems, and responsiveness to vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    . The overall rate of clinically significant psychiatric disorders was 51%, predominated by four diagnostic categories: episodic depression (10%), chronic disorders of behavior (17%), chronic obsessive\u2010compulsive disorder (5%), and personality disorders (19%). The average IQ was 80 \u00b1 27 (1 SD); and an IQ of \u2264 79 was two\u2010thirds more commom among vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    \u2010nonresponsive patients compared to vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    \u2010responsive patients. Aggressive behavior and other disorders of conduct were particularly common among patients with mental retardation and among vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    \u2010nonresponsive patients.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.1320260427","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T22:52:04Z","timestamp":1118530324000},"page":"959-969","source":"Crossref","is-referenced-by-count":102,"title":["Psychiatric manifestations of homocystinuria due to cystathionine \u03b2\u2010synthase deficiency: Prevalence, natural history, and relationship to neurologic impairment and vitamin B\n                    <sub>6<\/sub>\n                    \u2010responsiveness"],"prefix":"10.1002","volume":"26","author":[{"given":"Margaret H.","family":"Abbott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Folstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Abbey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reed E.","family":"Pyeritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,4]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"American Psychiatric Association(1980): \u201cDiagnostic and Statistical Manual of Mental Disorders.\u201d Third Edition Washington DC."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.2106\/00004623-196951080-00006","article-title":"Homocystinuria. 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Clinical manifestations and therapy","volume":"146","author":"Valle D","year":"1980","journal-title":"Johns Hopkins Med J"},{"key":"e_1_2_1_23_1","first-page":"13","volume-title":"Manual for the Wechsler Adult Intelligence Scale","author":"Wechsler D","year":"1955"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.115.519.163"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320260427","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320260427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T11:27:44Z","timestamp":1706268464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320260427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,4]]}},"alternative-id":["10.1002\/ajmg.1320260427"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320260427","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}