{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:40:44Z","timestamp":1791855644798,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T00:00:00Z","timestamp":1118275200000},"content-version":"vor","delay-in-days":6614,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report on a developmental malformation of the lung and kidney which has not been previously described and which we have chosen to call \u201ccystic hamartomata of the lung and kidney\u201d to emphasize the non\u2010malignant nature of these lesions. We also confirm a previous case report by Weinberg and Zumwalt [1977] as a different distinct disorder that results in a multifocal cystic hamartomata of the lung with associated marked parenchymal overgrowth of the kidney (the Weinberg\u2010Zumwalt syndrome). These cases represent a spectrum of abnormal morphogenesis affecting both kidney and lung. Patients 1 and 2 presented during infancy with abdominal masses and hypertension due to bilateral multilocular cysts of the kidney with associated hamartomatous pulmonary cysts; patient 2 also had one area of cellular mesoblastic nephroma. Patient 3 demonstrated markedly hyperplastic renomegaly with medullary dysplasia in association with bilateral cystic hamartomata of the lungs. During the fifth week of gestation, the ureteric bud invades the unsegmented mesoderm that becomes the metanephric system, and the lung bud invades the splanchic mesoderm, which provides the stimulus for its growth. We suggest that the predominant pattern of a congenital kidney or lung hamartoma might reflect the timing of a prenatal neoplastic event affecting these developmental processes.<\/jats:p>","DOI":"10.1002\/ajmg.1320270107","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:48:11Z","timestamp":1118544491000},"page":"45-59","source":"Crossref","is-referenced-by-count":17,"title":["Cystic hamartomata of lung and kidney: A spectrum of developmental abnormalities"],"prefix":"10.1002","volume":"27","author":[{"suffix":"Jr.","given":"John M.","family":"Graham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Troxell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry J.","family":"Cullity","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Sprague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Bruce","family":"Beckwith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(73)90213-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(74)80210-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711150307"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(77)90411-0"},{"key":"e_1_2_1_6_1","first-page":"71","volume-title":"Associated Congenital Anomalies","author":"Cohen MM","year":"1981"},{"key":"e_1_2_1_7_1","first-page":"120","volume-title":"The Child with Multiple Birth Defects","author":"Cohen MM","year":"1982"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.26.130.504"},{"key":"e_1_2_1_9_1","first-page":"89","article-title":"Cystadenorna of the kidney","volume":"43","author":"Edmunds W","year":"1892","journal-title":"Trans Path Soc [London]"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711050308"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196706)20:6<967::AID-CNCR2820200606>3.0.CO;2-P"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(81)80265-1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0022-5347(17)57001-9","article-title":"Bilateral multilocular renal cysts with recurrence","volume":"121","author":"Geller RA","year":"1979","journal-title":"J Urol"},{"key":"e_1_2_1_14_1","first-page":"1","volume-title":"Progress in Pediatrics","author":"Irving I","year":"1970"},{"key":"e_1_2_1_15_1","first-page":"31","article-title":"Congenital anomalies in children with malignancy, Paediat","volume":"16","author":"Kobayashi N","year":"1968","journal-title":"Univ Tokyo"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.146.2.6294736"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000129816"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80264-1"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1971.02100150092010"},{"key":"e_1_2_1_20_1","first-page":"374","article-title":"Case records of the Massachusetts General Hospital: Weekly clinicopathologic exercises","volume":"313","author":"Scully RE","year":"1985","journal-title":"New Engl J Med"},{"key":"e_1_2_1_21_1","first-page":"1137","article-title":"Canine bone sarcoma: estimate of relative risk as a function of body size","volume":"36","author":"Tjalma RA","year":"1966","journal-title":"J Niitl Cancer Fnd"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/67.3.284"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197303000-00005"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320270107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320270107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T13:16:38Z","timestamp":1697894198000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320270107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,5]]}},"alternative-id":["10.1002\/ajmg.1320270107"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320270107","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5]]}}}