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These findings were associated with normal endocrine function. Bizarre digital overgrowth, hemihypertrophy, thickened palms and soles, exostoses of the skull, and multiple hamartomata were common anomalies. Early overgrowth of limbs and digits occurred in several instances but the ultimate stature of 2 adults was normal. Surgical intervention offers cosmetic and orthopedic benefits, but these must be assessed in the light of potential post\u2010operative complications.<\/jats:p>","DOI":"10.1002\/ajmg.1320270110","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:48:11Z","timestamp":1118544491000},"page":"87-97","source":"Crossref","is-referenced-by-count":66,"title":["Proteus syndrome in Southern Africa: Natural history and clinical manifestations on six individuals"],"prefix":"10.1002","volume":"27","author":[{"given":"D. L.","family":"Viljoen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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