{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:31:38Z","timestamp":1762673498710},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T00:00:00Z","timestamp":1118275200000},"content-version":"vor","delay-in-days":6614,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have generated percentiles for the pattern variability index (\u03c3<jats:sub>z<\/jats:sub>) of the hand in 1,088 normal infants, children, and adults and have analyzed pattern variability indices for 820 individuals representing 50 congenital malformation syndromes with respect to the normal percentiles. The majority of the affected individuals exhibited elevated (\u03c3<jats:sub>z<\/jats:sub>) values for the hand, some vastly in excess of normal, while such syndromes as Down, Turner, and the Prader\u2010Willi syndrome were low rather than high in pattern variability of the hand.<\/jats:p>","DOI":"10.1002\/ajmg.1320270115","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:48:11Z","timestamp":1118544491000},"page":"143-152","source":"Crossref","is-referenced-by-count":15,"title":["Applications of the pattern variability index (\u03c3<sub>z<\/sub>) to the quantification of dysmorphogenesis in the hand"],"prefix":"10.1002","volume":"27","author":[{"given":"Stanley M.","family":"Garn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew K.","family":"Poznanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-349-05131-1","volume-title":"Birth Defects Compendium","author":"Bergsma D","year":"1979"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330430305"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/105.2.375"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.150.3.6695067"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.144.2.365"},{"key":"e_1_2_1_7_1","volume-title":"The Hand in Radiologic Diagnosis: With Gamuts and Pattern Profiles","author":"Poznanski AK","year":"1984"},{"key":"e_1_2_1_8_1","first-page":"89","article-title":"Pattern profile comparisons: Differences and similarities","volume":"27","author":"Poznanski AK","year":"1984","journal-title":"Ann Radiol"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320270115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320270115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T13:17:55Z","timestamp":1697894275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320270115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,5]]}},"alternative-id":["10.1002\/ajmg.1320270115"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320270115","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5]]}}}