{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T10:07:22Z","timestamp":1784110042835,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":6424,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Familial middle ear ossicular anomalies are rare. We report on a daughter and her mother with congenital conductive hearing loss. Tympanotomy disclosed hypoplasia of long crus of incus whose tip had been replaced with a fibrous strand.<\/jats:p><jats:p>A review suggests that middle ear ossicular anomalies may be inherited as autosomal dominant traits. Most individuals were bilaterally affected. Most isolated cases were affected unilaterally.<\/jats:p>","DOI":"10.1002\/ajmg.1320280313","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:49:50Z","timestamp":1118537390000},"page":"655-659","source":"Crossref","is-referenced-by-count":14,"title":["Familial ossicular malformations: Case report and review of literature"],"prefix":"10.1002","volume":"28","author":[{"given":"Koichiro","family":"Higashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Itani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Togawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"250","article-title":"Anomalies of the ossicles without malformations of the external ear","volume":"17","author":"Funasaka S","year":"1971","journal-title":"Otologia Fukuoka"},{"key":"e_1_2_1_3_1","first-page":"50","article-title":"Congenital ossicular abnormalities found in sibs","volume":"5","author":"Iwanaga Y","year":"1978","journal-title":"Clin Otol Jpn"},{"key":"e_1_2_1_4_1","first-page":"358","article-title":"Familial congenital middle ear anomaly (2nd report)","volume":"12","author":"Kitamura H","year":"1985","journal-title":"Clin Otol Jpn"},{"key":"e_1_2_1_5_1","first-page":"48","volume-title":"Genetic and Metabolic Deafness","author":"Konigsmark BW","year":"1976"},{"key":"e_1_2_1_6_1","first-page":"661","article-title":"A family with hereditary bilateral middle ear malformations","volume":"59","author":"Kumagawa K","year":"1984","journal-title":"Otolaryngol (Tokyo)"},{"key":"e_1_2_1_7_1","first-page":"360","article-title":"Congenital stapes fixation in a family with many patients","volume":"12","author":"Masuda Y","year":"1985","journal-title":"Clin Otol Jpn"},{"key":"e_1_2_1_8_1","first-page":"89","article-title":"Monopodal stapes in congenital conductive deafness, a report of five cases","volume":"46","author":"Morimitsu T","year":"1974","journal-title":"Otolaryngol (Tokyo)"},{"key":"e_1_2_1_9_1","first-page":"75","article-title":"Interesting cases with conductive deafness due to ossicular abnormality","volume":"54","author":"Murashima R","year":"1982","journal-title":"Otolaryngol (Tokyo)"},{"key":"e_1_2_1_10_1","first-page":"124","article-title":"Bilateral stapes fixation in a father and three daughters","volume":"3","author":"Onishi S","year":"1976","journal-title":"Clin Otol Jpn"},{"key":"e_1_2_1_11_1","first-page":"92","article-title":"Congenital ossicular discontinuity in sibs","volume":"8","author":"Yamada K","year":"1981","journal-title":"Clin Otol Jpn"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320280313","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320280313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T18:08:33Z","timestamp":1697911713000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320280313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,11]]}},"alternative-id":["10.1002\/ajmg.1320280313"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320280313","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11]]}}}