{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:06:10Z","timestamp":1761717970209},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,4]],"date-time":"2005-06-04T00:00:00Z","timestamp":1117843200000},"content-version":"vor","delay-in-days":6395,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1987,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inability to vomit has been cited as characteristic of Prader\u2010Willi syndrome (PWS). Although post\u2010prandial vomiting after gastric by\u2010pass surgery has been reported, neither vomiting under \u201ctypical\u201d circumstances or rumination have been described. Prompted by the discovery of several cases of vomiting and rumination, a questionnaire was sent to members of the PWS Association. Approximately 36% (113\/313) of affected individuals reportedly experienced at least one episode of vomiting. Induced vomiting was unsuccessful in 9 of 14 cases in whom results were known. However, no complications of Ipecac were reported. We suggest that there is an alteration in the physiologic set\u2010point at which vomiting occurs, leading to a decreased propensity to vomit. Liberal and strict definitions of rumination yielded 15.7% and 10.2% positive responses, respectively. Rumination was associated with a history of vomiting. Enamel deterioration consistent with rumination has been observed, and such changes should be looked for in all PWS children. In several instances, rumination was found to decrease when very strict weight control was lessened. Certain individuals may ruminate under too strict a weight control program, and weight control goals should be evaluated to achieve a reasonable compromise between ideal weight and obesity. Vomiting and rumination do not rule out the diagnosis of PWS.<\/jats:p>","DOI":"10.1002\/ajmg.1320280414","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:52:33Z","timestamp":1118544753000},"page":"889-895","source":"Crossref","is-referenced-by-count":19,"title":["Rumination and vomiting in Prader\u2010Willi syndrome"],"prefix":"10.1002","volume":"28","author":[{"given":"Randell C.","family":"Alexander","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise R.","family":"Greenswag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur J.","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Ledbetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,4]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Beltran D [ed] (1985):Medical alert. In the Prader\u2010Willi Syndrome Association Newsletter:21."},{"key":"e_1_2_1_3_1","first-page":"3","article-title":"Prader\u2010Willi syndrome","volume":"14","author":"Cassidy SB","year":"1984","journal-title":"Curr Prob Pediatr"},{"key":"e_1_2_1_4_1","first-page":"924","article-title":"Rumination: Etiology and treatment","volume":"13","author":"Chatoor M","year":"1984","journal-title":"Pediatr Ann"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1985.tb04540.x"},{"key":"e_1_2_1_6_1","first-page":"27","volume-title":"Prader\u2010Willi Syndrome","author":"Hanson JW","year":"1981"},{"key":"e_1_2_1_7_1","first-page":"65","article-title":"Dental effects and management of bulemia nervosa","volume":"33","author":"Harrison JL","year":"1984","journal-title":"Gen Dent"},{"key":"e_1_2_1_8_1","first-page":"27","volume-title":"Prader\u2010Willi Syndrome","author":"Holm VA"},{"key":"e_1_2_1_9_1","first-page":"121","volume-title":"Prader\u2010Willi Syndrome","author":"Soper RT","year":"1981"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1978.0396"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198508000-00009"},{"key":"e_1_2_1_12_1","first-page":"588","article-title":"Syndrome of hypotonia\u2010hypomentia\u2010hypogonadism\u2010obesity (HHHO) or Prader\u2010Willi syndrome","volume":"115","author":"Zellweger H","year":"1968","journal-title":"Am J Dis Child"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320280414","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320280414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T13:23:30Z","timestamp":1697894610000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320280414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,12]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,12]]}},"alternative-id":["10.1002\/ajmg.1320280414"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320280414","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,12]]}}}