{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T23:26:18Z","timestamp":1743463578064},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,5]],"date-time":"2005-06-05T00:00:00Z","timestamp":1117929600000},"content-version":"vor","delay-in-days":6274,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Antley\u2010Bixler syndrome (ABS) is characterized by craniosynostosis, radiohumeral synostosis, and femoral bowing. Other findings include a trapezoid\u2010shaped head, deformed ears, severe midface hypoplasia, choanal atresiaor stenosis, and long bone fractures. Most ABS cases have died in the firstmonths of life from respiratory complications. The poor prognosis in this condition makes counseling difficult and early termination of pregnancy a consideration. The medical and surgical management information presented herecan be used as a guide for counseling parents in the future.<\/jats:p><jats:p>We report on a new patient with ABS who now at age 3 yr, has been followed by the medical staff of Riley Children's Hospital since birth. She has had successful medical and surgical management.<\/jats:p><jats:p>Although the multisynostoses seen in this disorder is undoubtedly related to the soft tissue malformations such as choanal stenosis and midface hypoplasia, the cause remains unknown. The literature is also reviewed in this condition.<\/jats:p>","DOI":"10.1002\/ajmg.1320290412","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:13:44Z","timestamp":1118546024000},"page":"829-836","source":"Crossref","is-referenced-by-count":28,"title":["Antley\u2010Bixler syndrome from a prognostic perspective. Report of a case and review of the literature"],"prefix":"10.1002","volume":"29","author":[{"given":"Luis F.","family":"Escobar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bixler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sadove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn J.","family":"Bull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,5]]},"reference":[{"issue":"2","key":"e_1_2_1_2_1","first-page":"397","article-title":"Trapezoidocephaly, midface hypoplasia and cartilage abnormalities with multiple synostosis and skeletal fractures","author":"Antley R","year":"1975","journal-title":"BD: OAS"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2106\/00004623-198567040-00006","article-title":"Congenital proximal radio\u2010ulnar synostosis. Natural history and functional assessment","volume":"67","author":"Cleary J","year":"1985","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_4_1","first-page":"1","volume-title":"Craniosynostosis: Diagnosis, Evaluation, and Management","author":"Cohen M","year":"1986"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320070322"},{"key":"e_1_2_1_6_1","first-page":"169","article-title":"L'acrocephalosynankie a propos d'une observation avec synostoses multiples","volume":"39","author":"Lacheretz M","year":"1974","journal-title":"Pediatrie"},{"key":"e_1_2_1_7_1","first-page":"291","article-title":"Le syndrome D'Antley\u2010Bixler. revue de la litterature a propos d'une observation personelle","volume":"32","author":"Robert E","year":"1984","journal-title":"J Genet Hum"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80117-0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970020311"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320140119"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01876602"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320290412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320290412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T23:48:28Z","timestamp":1697845708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320290412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,4]]}},"alternative-id":["10.1002\/ajmg.1320290412"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320290412","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,4]]}}}