{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:08:11Z","timestamp":1778670491660,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":6272,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic multicentric osteolysis is a rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis. Progressive destruction of the carpal and tarsal bones usually occurs and other bones may also be involved. Chronic renal failure is a frequent component of this syndrome. Mental retardation and minor facial abnormalities have been noted in some patients. We report on 2 unrelated, sporadic cases, one with facial anomalies and the other with nephropathy. Our second patient is the first black child to be diagnosed with this disease. The mode of presentation, differential diagnosis, and natural history of this disorder are briefly reviewed.<\/jats:p>","DOI":"10.1002\/ajmg.1320290425","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:13:44Z","timestamp":1118546024000},"page":"929-936","source":"Crossref","is-referenced-by-count":31,"title":["Idiopathic multicentric osteolysis. Report of two new cases and a review of the literature"],"prefix":"10.1002","volume":"29","author":[{"given":"G. S.","family":"Pai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. I.","family":"Macpherson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Optiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2106\/00004623-197557050-00020","article-title":"Carpal and tarsal osteolysis: A case report and review of the litcrature","volume":"57","author":"Beals RK","year":"1975","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000181769"},{"key":"e_1_2_1_4_1","first-page":"1179","volume-title":"Pediatric X\u2010Ray Diagnosis","author":"Caffey J","year":"1972"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260415"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)81076-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80177-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-195537050-00008"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00440497"},{"key":"e_1_2_1_10_1","first-page":"145","article-title":"Chronic nephropathy in idiopathic multicentric osteolysis","volume":"6","author":"Hirooka M","year":"1985","journal-title":"Int J Pediatr Nephrol"},{"key":"e_1_2_1_11_1","first-page":"368","article-title":"A boneless arm","volume":"18","author":"Jackson JBS","year":"1838","journal-title":"Boston Med Surg J"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/108.1.99"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1302\/0301-620X.47B2.339","article-title":"Osteoarticular changes in a case of essential osteolysis. An anatomical and radiological study","volume":"47","author":"Lagier RL","year":"1965","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.2106\/00004623-197254050-00021","article-title":"Carpal and tarsal agenesis with features of essential hereditary osteolysis","volume":"54","author":"McManus LF","year":"1972","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_15_1","first-page":"98","article-title":"Essential osteolysis with nephropathy","volume":"24","author":"Macpherson RI","year":"1973","journal-title":"J Can Assoc Radiol"},{"key":"e_1_2_1_16_1","first-page":"165","article-title":"Idiopathic multicentric osteolysis in a 78\u2010year old woman","volume":"148","author":"Renie WA","year":"1981","journal-title":"Johns Hopkins Med J"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03060300025005"},{"key":"e_1_2_1_18_1","first-page":"1858","article-title":"Forme speciale d'ostelyse essentielle hereditaire et familiale a stabilsation spontanee dans l'enfance","volume":"66","author":"Thieffry S","year":"1958","journal-title":"Press Med"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1302\/0301-620X.67B1.3968151","article-title":"Idiopathic multicentric osteolysis with acro\u2010osteolysis","volume":"67","author":"Tookman AG","year":"1985","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(69)80395-1"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00866883"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.126.1.23"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210313"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.106.1.121"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320290425","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320290425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T23:48:17Z","timestamp":1697845697000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320290425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,4]]}},"alternative-id":["10.1002\/ajmg.1320290425"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320290425","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,4]]}}}