{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:05:51Z","timestamp":1763366751231},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,5]],"date-time":"2005-06-05T00:00:00Z","timestamp":1117929600000},"content-version":"vor","delay-in-days":6121,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The California AFP Screening Program was developed to offer pregnant women the opportunity to have their pregnancies screened for open neural tube defects (NTD). Because it is unwise to withhold potentially important clinical information about low MS\u2010AFP results from the screened women and their physicians, follow\u2010up diagnostic evaluations and counseling were offered to women with low MS\u2010AFP results in addition to those with high results or positive family histories of NTD.<\/jats:p><jats:p>Between April 7, 1986 and September 30, 1987, over 275,000 women voluntarily participated in the screening program. During the first year of the program 3,939 women were seen for follow\u2010up evaluations due to low MS\u2010AFP results. These evaluations occurred at state\u2010approved AFP follow\u2010up centers where ultrasonographic dating led to reinterpretation of 35% of the results. Of the remaining 2,552 (65%), 1,940 women (76%) had an amniocentesis. Sixteen Down syndrome fetuses were detected for a yield of 1\/121 amniocenteses. Additional chromosome abnormalities included trisomies 18 and 13, Ullrich\u2010Turner syndrome, (45,X), Klinefelter syndrome (47,XXY) and triploidy. The total yield of significant chromosome abnormalities was 1\/78 amniocenteses.<\/jats:p>","DOI":"10.1002\/ajmg.1320310128","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:19:12Z","timestamp":1118546352000},"page":"211-222","source":"Crossref","is-referenced-by-count":22,"title":["California's experience with low MS\u2010AFP results"],"prefix":"10.1002","volume":"31","author":[{"given":"Linda","family":"Lustig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda","family":"Schonberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwynne","family":"Tompkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)80062-9"},{"key":"e_1_2_1_3_1","first-page":"75","article-title":"Policy statement for maternal serum alpha\u2010fetoprotein screening programs and quality control for laboratories performing maternal serum and amniotic fluid alpha\u2010fetoprotein assays","volume":"40","author":"American Society of Human Genetics","year":"1987","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/clinchem\/29.3.531","article-title":"Alpha\u2010fetoprotein concentrations in maternal serum: Relation to race and body weight","volume":"29","author":"Crandall BF","year":"1983","journal-title":"Clin Chem"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92389-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb03115.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198708063170603"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"HaddowJE PalomakiGE WaldNJ CuckleHS(1986):Maternal serum alpha\u2010fetoprotein screening for Down syndrome and repeat testing. 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