{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T19:22:10Z","timestamp":1698261730205},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":6119,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The economic consequences of using an index of maternal age and maternal serum alpha\u2010fetoprotein (MSAFP) screening to indicate risk of Down syndrome (DS) are examined. If DS screening indicated solely by a given maternal age is economically justifiable, then amniocentesis indicated by a DS risk equivalent to that maternal age cutoff, but based on an index of maternal age (for ages below the cutoff) and low MSAFP results, is also economically justifiable. It is concluded that the extant use of MSAFP screening for DS is a move toward the cost\u2010effective use of scarce resources that can be made available with coordinated planning. However, increased professional and public awareness may result in significant increases in aggregate demand for these services. While MSAFP screening for DS is economically justifiable, there exists some potential for bottlenecks at the aggregate level, and these should be considered in conjunction with recommendations that the technology be adopted on a widespread basis.<\/jats:p>","DOI":"10.1002\/ajmg.1320310130","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:19:12Z","timestamp":1118546352000},"page":"231-245","source":"Crossref","is-referenced-by-count":7,"title":["Maternal serum alpha\u2010fetoprotein screening for down syndrome: Economic considerations"],"prefix":"10.1002","volume":"31","author":[{"given":"J. Michael","family":"Swint","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Centers for Disease Control Atlanta(1978):Mental Retardation birth defects and genetic disease control programs: A cost\u2010benefit analysis(unpublished manuscript) 1978."},{"key":"e_1_2_1_3_1","first-page":"442","volume-title":"The Prevention of Genetic Disease and Mental Retardation","author":"Conley R","year":"1975"},{"key":"e_1_2_1_4_1","volume-title":"Projection of the Population of the United States, by Age, Sex, and Race, 1983 to 2080","author":"Current Population Reports, Series P\u201025, No. 952","year":"1984"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198412133112411"},{"key":"e_1_2_1_6_1","first-page":"123","volume-title":"Numerical Taxonomy of Birth Defects and Polygenic Disorders","author":"Hook EB","year":"1977"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420170303"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.69.6.566"},{"key":"e_1_2_1_9_1","first-page":"1","volume-title":"Induced Terminations of Pregnancy, Reporting States, 1984","author":"National Center for Health Statistics, Monthly Vital Statistics Report","year":"1987"},{"key":"e_1_2_1_10_1","first-page":"160","article-title":"An economic evaluation of a genetic screening program for Tay\u2010Sachs disease","volume":"30","author":"Nelson W","year":"1978","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320100409"},{"key":"e_1_2_1_12_1","first-page":"8","volume-title":"Frontiers in Genetic Medicine","author":"Swint JM","year":"1987"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-4704-7_7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(79)90320-7"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320310130","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320310130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:02:19Z","timestamp":1697878939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320310130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1002\/ajmg.1320310130"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320310130","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]}}}