{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:19:46Z","timestamp":1790299186524,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,5]],"date-time":"2005-06-05T00:00:00Z","timestamp":1117929600000},"content-version":"vor","delay-in-days":6091,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the neurodevelopmental status and cognitive ability of 30 school\u2010age children with Marfan syndrome. We found average intellectual (mean full scale IQ = 109.3) and gross motor development. Fifty percent had one or more neuropsychologic deficits: learning disability (LD) (13%), attention deficit disorder with or without hyperactivity (ADD \u00b1 H) (17%), neuromaturational immaturity (NMI) (10%), and a performance IQ score different from their verbal score by more than 20 points (30%). Patients with a large verbal\u2010performance discrepancy, with one exception, scored lower on tests of performance, and particularly low on two subtests, object assembly and coding, compared with the rest of the patients (<jats:italic>P<\/jats:italic> &lt; 0.01). The factor most highly correlated with verbal\u2010performance discrepancy was the severity of joint hypermobility (<jats:italic>P<\/jats:italic> = 0.02), which suggests that the depressed performance score was due, in part, to motor incoordination. Children with Marfan syndrome may be prone to neuropsychologic problems; the role of routine screening remains to be tested. Those with hand\u2010wrist hypermobility seem at particular risk for difficulties with tasks that involve writing and should receive careful evaluation in the classroom. Due to the high risk of aortic dilatation in these patients, if stimulant medications are considered for treatment of ADD \u00b1 H, the risk of adverse sympathomimetic effect should be weighed against the potential benefit.<\/jats:p>","DOI":"10.1002\/ajmg.1320310210","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:19:17Z","timestamp":1118546357000},"page":"331-338","source":"Crossref","is-referenced-by-count":41,"title":["Marfan syndrome: Neuropsychological aspects"],"prefix":"10.1002","volume":"31","author":[{"given":"Karen J.","family":"Hofman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Bernhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reed E.","family":"Pyeritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,5]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"American Psychiatric Association(1980): \u201cDiagnostic and Statistical Manual of Mental Disorders (DSM III) \u201d 3rd ed. Washington DC p43."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1985.tb14136.x"},{"key":"e_1_2_1_4_1","first-page":"55","article-title":"Rating scales for drug studies in children","volume":"10","author":"Conners CK","year":"1973","journal-title":"Psychopharm Bull"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1973.tb05174.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(69)90054-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1542\/peds.74.1.150","article-title":"Learning disabilities, dyslexia and vision","volume":"74","author":"Fremont AC","year":"1984","journal-title":"Pediatrics"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.16.5097"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/2089217"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(84)90568-X"},{"key":"e_1_2_1_11_1","first-page":"20","volume-title":"Intelligent Testing with the WISC\u2010R","author":"Kaufman AS","year":"1979"},{"key":"e_1_2_1_12_1","first-page":"61","volume-title":"Heritable Disorders of Connective Tissue","author":"McKusick VA","year":"1972"},{"key":"e_1_2_1_13_1","first-page":"50","volume-title":"Minimal Brain Dysfunction: A Prospective Study","author":"Nichols PL","year":"1981"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.2307\/1129698"},{"key":"e_1_2_1_15_1","article-title":"Education for all handicapped act","volume":"42478","author":"Public Law 94\u2013142","year":"1975","journal-title":"Federal Register"},{"issue":"6","key":"e_1_2_1_16_1","first-page":"83","article-title":"The Marfan syndrome","volume":"34","author":"Pyeritz RE","year":"1986","journal-title":"Am Fam Phys"},{"key":"e_1_2_1_17_1","first-page":"469","article-title":"Protection of the aortic root by propranolol in Marfan syndrome","volume":"23","author":"Pyeritz RE","year":"1986","journal-title":"J Med Genet"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197904053001406"},{"key":"e_1_2_1_19_1","article-title":"Dural ectasia is a common feature of the Marfan syndrome","volume":"43","author":"Pyeritz RE","year":"1988","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-7138(09)60996-1"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(83)90138-8"},{"issue":"4","key":"e_1_2_1_22_1","first-page":"87","article-title":"Patient acceptability of propranolol and the occurrence of side effects","volume":"52","author":"Zacharias FJ","year":"1976","journal-title":"Postgrad Med J"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320310210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320310210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T04:03:30Z","timestamp":1697861010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320310210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1002\/ajmg.1320310210"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320310210","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10]]}}}