{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:34:31Z","timestamp":1770824071999,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":5966,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report on a newborn male with deletion of part of 11q, the 27th reported case. Our patient had some of the clinical characteristics of the 11q\u2013syndrome, but his male gender, liveborn status, q21 breakpoint, and mosaicism were unusual. In addition, he demonstrated holoprosencephaly, with cyclopia and arhinencephaly, manifestations previously unreported in the 11q\u2013syndrome. We discuss the above points and review the literature on 11q\u2013.<\/jats:p>","DOI":"10.1002\/ajmg.1320320207","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:54:16Z","timestamp":1118544856000},"page":"178-181","source":"Crossref","is-referenced-by-count":22,"title":["Holoprosencephaly, ear abnormalities, congenital heart defect, and microphallus in a patient with 11q\u2013mosaicism"],"prefix":"10.1002","volume":"32","author":[{"given":"Robin A.","family":"Helmuth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R.","family":"Wills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"63","article-title":"Monosomie partielle 11q","volume":"20","author":"Bresson JL","year":"1977","journal-title":"Ann Genet (Paris)"},{"key":"e_1_2_1_3_1","first-page":"67","article-title":"Trigonocephaly and the 11q\u2013 syndrome","volume":"20","author":"Cassidy SB","year":"1977","journal-title":"Ann Genet (Paris)"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80349-1"},{"key":"e_1_2_1_5_1","first-page":"473","article-title":"Chromosome 11 long arm partial deletion: A new syndrome","volume":"80","author":"Engel E","year":"1976","journal-title":"Am J Ment Defic"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1974.tb00637.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1979.tb05073.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00393977"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000152624"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1977.tb00950.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320270105"},{"key":"e_1_2_1_12_1","volume-title":"Cytogenetics, Environment, and Malformation Syndromes","author":"Larson SA","year":"1976"},{"issue":"5","key":"e_1_2_1_12_2","first-page":"125","author":"National Foundation\u2010March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_13_1","first-page":"239","article-title":"Deux nouveaus cas de monosomie 11q partielle avec point de cassure en 11q24","volume":"22","author":"Laurent C","year":"1979","journal-title":"Ann Genet (Paris)"},{"key":"e_1_2_1_14_1","first-page":"51","article-title":"Partial monosomy of the long arm of chromosome 11 in a severely affected child","volume":"24","author":"Lee ML","year":"1981","journal-title":"Ann Genet (Paris)"},{"key":"e_1_2_1_15_1","first-page":"115","article-title":"Monosomie partielle par de'le'tion du bras long du chromosome 11: del (11) (q23)","volume":"22","author":"Leonard C.","year":"1979","journal-title":"Ann Genet (Paris)"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80366-0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.17.6.480"},{"key":"e_1_2_1_18_1","volume-title":"Dysmorphology (Annual Review of Brith Defects, 1981)","author":"McPherson E","year":"1982"},{"issue":"3","key":"e_1_2_1_18_2","first-page":"295","author":"National Foundation\u2010March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80823-2"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320130312"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00273264"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320180119"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.14.6.438"},{"key":"e_1_2_1_24_1","first-page":"61","article-title":"De'le'tion interstitielle du bras long d'un chromosome 11","volume":"18","author":"Taillemite JL","year":"1975","journal-title":"Ann Genet (Paris)"},{"key":"e_1_2_1_25_1","first-page":"257","article-title":"Monosomie partielle 11 q et trigonace'phalie. 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