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This patient confirms the localization of XLI, XLK, and CPXR to this region of the X chromosome and represents an example of a \u201ccontiguous gene syndrome.\u201d<\/jats:p><jats:p>A comparison of the manifestations of patients with CPXR, warfarin embryopathy, and vitamin K epoxide reductase deficiency shows a remarkable similarity. However, vitamin K epoxide reductase deficiency does not appear to be the cause of CPXR. We propose that CPXR may be due to a defect in a vitamin K\u2010dependent bone protein such as vitamin K\u2010dependent bone carboxylase, osteocalcin, or matrix Gla protein.<\/jats:p>","DOI":"10.1002\/ajmg.1320330114","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:59:47Z","timestamp":1118545187000},"page":"100-107","source":"Crossref","is-referenced-by-count":60,"title":["Male infant with ichthyosis, Kallmann syndrome, chondrodysplasia punctata, and an Xp chromosome deletion"],"prefix":"10.1002","volume":"33","author":[{"given":"David","family":"Bick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia J. 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