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Diagnostic measures included cranial computer tomography (CT) and magnetic resonance imaging (MRI) scanning, several in vivo and in vitro immunological tests, and histology of skin, lymph nodes, and liver including electron microscopy and immunohistology. Despite medical supervision, the child died at age 4 years.<\/jats:p><jats:p>A common pathogenetic mechanism of defective migration of neurons and the dysmaturation of lymph nodes is most probable. The T\u2010cell deficiency may represent a common defect of the development of both neuronal and lymphatic tissue, as the six\u2010layered cerebral cortex and the B\u2010cell areas in lymph nodes develop at about the same gestational age. A common defect could also be assumed involving genetically determined cell surface proteins.<\/jats:p>","DOI":"10.1002\/ajmg.1320330403","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:06:58Z","timestamp":1118545618000},"page":"436-443","source":"Crossref","is-referenced-by-count":10,"title":["Lissencephaly, abnormal lymph nodes, and T\u2010cell deficiency in one patient"],"prefix":"10.1002","volume":"33","author":[{"given":"M. B.","family":"Krawinkel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Feller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. D.","family":"Flad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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