{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:10:52Z","timestamp":1792152652625,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,5]],"date-time":"2005-06-05T00:00:00Z","timestamp":1117929600000},"content-version":"vor","delay-in-days":5726,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Otocephaly (\u201cagnathia\u201d) is a developmental field complex with structural defects limited to the craniofacial region. Previously, two infants with otocephaly, situs inversus totalis, renal defects, and vertebral and rib abnormalities were reported by Pauli et al. [Teratology 23:85\u201393, 1981]. We describe a similarly affected infant male, supporting the existence of this midline malformation association. A generalized disturbance in cell migration from the primitive streak may be its pathogenesis. A search for additional patients among cases of otocephaly may establish its prevalence, patterns of associated anomalies, and cause.<\/jats:p>","DOI":"10.1002\/ajmg.1320340223","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:56:55Z","timestamp":1118537815000},"page":"246-249","source":"Crossref","is-referenced-by-count":23,"title":["Otocephaly\u2010midline malformation association"],"prefix":"10.1002","volume":"34","author":[{"given":"Joseph H.","family":"Hersh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"McChane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William H.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Corrigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Pancratz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"164","volume-title":"Die Missbildingen des Menschen","author":"Ahlfeld JF","year":"1882"},{"key":"e_1_2_1_3_1","first-page":"423","volume-title":"Manual of Antenatal Pathology and Hygiene","author":"Ballantyne JW","year":"1905"},{"key":"e_1_2_1_4_1","first-page":"241","article-title":"Agnathia\u2010holoprosencephaly: A developmental field complex involving face and brain. Report of three cases","volume":"1","author":"Bixler D","year":"1985","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_1_5_1","first-page":"339","article-title":"Agnathia in sheep: External observations","volume":"30","author":"Dennis SM","year":"1972","journal-title":"Am J Vet Res"},{"key":"e_1_2_1_6_1","first-page":"2","article-title":"Reconstruction of brain and ventricle system in an anchyote prosophthalmic otocephalic newborn cephalothoracopagus rabbit","volume":"73","author":"Faller A","year":"1969","journal-title":"Acta Anat"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.19.1.78"},{"key":"e_1_2_1_8_1","first-page":"47","article-title":"Morphogenesis of spontaneously occurring otocephaly in a newly developed mouse mutant","volume":"21","author":"Juriloff DM","year":"1980","journal-title":"Teratology"},{"key":"e_1_2_1_9_1","first-page":"121","article-title":"Genetic and developmental studies of a new mouse mutation that produces otocephaly","volume":"5","author":"Juriloff DM","year":"1985","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290303"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310205"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb00854.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1980.tb00139.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230111"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320140411"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1542\/peds.67.2.176","article-title":"The axial mesodermal dysplasia spectrum","volume":"67","author":"Russell LJ","year":"1981","journal-title":"Pediatrics"},{"issue":"1","key":"e_1_2_1_17_1","first-page":"815","article-title":"In utero diagnosis of agnathia, microstomia and synotia","volume":"49","author":"Scholl HW","year":"1977","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1968.tb09000.x"},{"key":"e_1_2_1_19_1","first-page":"388","article-title":"Storia della Teratologia","volume":"6","author":"Taruffi C","year":"1891","journal-title":"Regia Tipographia (Bologna)"},{"key":"e_1_2_1_20_1","first-page":"399","article-title":"Storia della Teratologia","volume":"8","author":"Taruffi C","year":"1894","journal-title":"Regio Tipographia (Bologna)"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1972.tb15778.x"},{"key":"e_1_2_1_22_1","first-page":"58","article-title":"Congenital otocephalus in a lamb","volume":"61","author":"Willson JE","year":"1966","journal-title":"Vet Med Small Anim Clin"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/genetics\/19.6.471","article-title":"On the genetics of subnormal development of the head (otocephaly) in the guinea pig","volume":"19","author":"Wright S","year":"1934","journal-title":"Genetics"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030560413"},{"key":"e_1_2_1_25_1","first-page":"161","article-title":"Factors which determine otocephaly in guinea pigs","volume":"26","author":"Wright S","year":"1923","journal-title":"J Agric Res"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000540303"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320340223","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320340223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T01:48:41Z","timestamp":1697939321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320340223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,10]]}},"alternative-id":["10.1002\/ajmg.1320340223"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320340223","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,10]]}}}