{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:12:19Z","timestamp":1777104739725,"version":"3.51.4"},"reference-count":165,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,5]],"date-time":"2005-06-05T00:00:00Z","timestamp":1117929600000},"content-version":"vor","delay-in-days":5726,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This paper attempts to balance our knowledge of holoprosencephalic spectra and continuities with important distinctions and discontinuities. Prevalence studies and syndrome delineation are briefly reviewed. The following topics receive detailed coverage: human teratogens, special aspects of forebrain and hindbrain malformations, aprosencephaly\/atelencephaly, association with neural tube defects, current assessment of \u201cfacial principles,\u201d and endocrine abnormalities.<\/jats:p>","DOI":"10.1002\/ajmg.1320340232","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:56:55Z","timestamp":1118537815000},"page":"271-288","source":"Crossref","is-referenced-by-count":189,"title":["Perspectives on holoprosencephaly: Part III. Spectra, distinctions, continuities, and discontinuities"],"prefix":"10.1002","volume":"34","author":[{"suffix":"Jr.","given":"M. Michael","family":"Cohen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(65)90018-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320030312"},{"key":"e_1_2_1_4_1","volume-title":"Congenital Facial Anomalies With Neurologic Defects","author":"Aita JA","year":"1969"},{"key":"e_1_2_1_5_1","first-page":"53","article-title":"Microcephaly in familial holoprosencephaly","volume":"8","author":"Ardinger HH","year":"1988","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_1_6_1","first-page":"145","article-title":"Essential hypernatraemia, antidiuretic hormone and neurophysin secretion: Response to chlorpropamide","volume":"96","author":"AvRuskin TW","year":"1981","journal-title":"Acta Endocrinol (Copenh)"},{"key":"e_1_2_1_7_1","volume-title":"Antenatal Pathology and Hygiene","author":"Ballantyne JW","year":"1904"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80185-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1399-0004.1987.tb02826.x","article-title":"Single maxillary central incisor and coloboma in hypomelanosis of Ito","volume":"2","author":"Bartholomew DW","year":"1987","journal-title":"Clin Genet"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90791-0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320070312"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80645-7"},{"key":"e_1_2_1_13_1","first-page":"365","article-title":"An unusual case of median cleft lip with obital hypotelorism\u2014a missing link in the classification","volume":"15","author":"Ben\u2010Hur N","year":"1978","journal-title":"Cleft Palate J"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340224"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80485-0"},{"key":"e_1_2_1_16_1","first-page":"241","article-title":"Agnathia\u2010holoprosencephaly: A developmental field complex including face and brain. Report of 3 cases","volume":"1","author":"Bixler D","year":"1985","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320210118"},{"key":"e_1_2_1_18_1","first-page":"173","article-title":"An erupted tooth in a cyclops foetus","volume":"17","author":"Boyd JD","year":"1951","journal-title":"Br Dent J"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320110409"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320280110"},{"key":"e_1_2_1_21_1","series-title":"BD:OAS","first-page":"215","volume-title":"Recent Advances and New Syndromes. Annual Review of Birth Defects, 1977","author":"Cant\u00fa J\u2010M","year":"1978"},{"key":"e_1_2_1_22_1","first-page":"107","article-title":"Cyclopia\u2010otocephaly association: A new case of the most severe variant of agnathia\u2010holoprosencephaly complex","volume":"7","author":"Carles D","year":"1987","journal-title":"J Graniofac Genet Dev Biol"},{"key":"e_1_2_1_23_1","first-page":"647","article-title":"Deux cas de cyclopie","volume":"23","author":"Castel Y","year":"1976","journal-title":"Ann P\u00e9diatr (Paris)"},{"key":"e_1_2_1_24_1","first-page":"597","article-title":"Holoprosencephaly revisited","volume":"127","author":"Cohen MM","year":"1974","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_25_1","first-page":"885","article-title":"An update on the holoprosencephalic disorders","volume":"101","author":"Cohen MM","year":"1982","journal-title":"J Pediatr"},{"key":"e_1_2_1_26_1","first-page":"576","volume-title":"Principles and Practice of Medical Genetics","author":"Cohen MM","year":"1983"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","unstructured":"CohenMM Jr(1989a): Perspectives on holoprosencephaly. Part I. Epidemiology genetics and syndromology.Teratology in press.","DOI":"10.1002\/tera.1420400304"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340229"},{"key":"e_1_2_1_29_1","series-title":"BD:OAS","first-page":"113","volume-title":"The Clinical Delineation of Birth Defects: Part II, Malformation Syndrome","author":"Cohen MM","year":"1969"},{"key":"e_1_2_1_30_1","series-title":"Publication No (NIH) 76\u2013989","first-page":"383","volume-title":"Development of the Basicranium","author":"Cohen MM","year":"1976"},{"key":"e_1_2_1_31_1","series-title":"BD:OAS","first-page":"125","volume-title":"Clinical Delineation of Birth Defects: Part XI, Orofacial Structures","author":"Cohen MM","year":"1971"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420250206"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1972.tb04272.x"},{"key":"e_1_2_1_34_1","unstructured":"CohenMM Jr SulikKK(1989): Perspectives on holoprosencephaly. Part II. Central nervous system craniofacial anatomy syndrome commentary diagnostic approach and experimental studies.J Craniofac Genet Dev Biol in press."},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060090096024"},{"key":"e_1_2_1_36_1","series-title":"BD:OAS","first-page":"74","volume-title":"The Clinical Delineation of Birth Defects: Part V, Phenotypic Aspects of Chromosomal Abberations","author":"de Grouchy J","year":"1969"},{"key":"e_1_2_1_37_1","first-page":"181","article-title":"Cleft lip and jaw induced in fetal rats by vincristine","volume":"48","author":"DeMyer W","year":"1965","journal-title":"Arch Anat Histol Embryol (Strasb)"},{"key":"e_1_2_1_38_1","first-page":"431","volume-title":"Handbook of Clinical Neurology","author":"DeMyer W","year":"1977"},{"key":"e_1_2_1_39_1","unstructured":"DeMyerWE(1978): Personal communication."},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000104278"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.13.11.913"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.34.2.256"},{"key":"e_1_2_1_43_1","first-page":"277","article-title":"Trisomie 13\u201315. \u00c9tudie anatomico\u2010pathologique d'une forme rare avec ethmoc\u00e9phalie","volume":"15","author":"Diebold J","year":"1967","journal-title":"Arch Anat Pathol (Franc)"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.18.5.396"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00497681"},{"key":"e_1_2_1_46_1","unstructured":"FlanneryDB BillingsleyG SmithAT PierceKL(1988):A new feature in the single maxillary central incisor\u2010holoprosencephaly syndrome. 9th Annual David W. Smith Workshop on Malformations and Morphogenesis Oakland California August 3\u20137."},{"key":"e_1_2_1_47_1","first-page":"315","article-title":"Hypophysarer Zwergwuchs bei Lippen\u2010Kiefer\u2010Spalte","volume":"21","author":"Frances JM","year":"1966","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.8.3.285"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80129-7"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80017-7"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000143308"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320300411"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.19.1.78"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1977.tb07973.x"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(71)90178-2"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1974.tb02261.x"},{"key":"e_1_2_1_57_1","series-title":"BD:OAS","first-page":"239","volume-title":"Growth Problems and Clinical Advances","author":"Gilbert EF","year":"1976"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.3406\/bch.1976.2046"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00281680"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091850"},{"key":"e_1_2_1_61_1","first-page":"391","article-title":"Trisomy D in cyclops. A case report","volume":"37","author":"Halbrecht I","year":"1971","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320070110"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1980.02130150039010"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320280226"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(68)80403-2"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970080909"},{"key":"e_1_2_1_67_1","series-title":"BD:OAS","first-page":"377","volume-title":"Sex Differentiation and Chromosome Abnormalities. Annual Review of Birth Defects","author":"Hodes ME","year":"1978"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.11.1.35"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.14.4.291"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80142-5"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1977.tb08000.x"},{"key":"e_1_2_1_72_1","first-page":"199","article-title":"Autosomal dominant inheritance of the DeMyer sequence","volume":"8","author":"Jaramillo C","year":"1988","journal-title":"J Craniofac Gent Dev Biol"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00691523"},{"key":"e_1_2_1_74_1","unstructured":"JohnstonMC(1981): Personal communication."},{"key":"e_1_2_1_75_1","first-page":"120","article-title":"Cyclopia","volume":"125","author":"Khudr G","year":"1973","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_76_1","first-page":"246","article-title":"\u00dcber die Arhinenzephalie","volume":"88","author":"K\u00f6hn K","year":"1952","journal-title":"Zentralbl Allg Pathol"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420260202"},{"key":"e_1_2_1_78_1","unstructured":"KosterK(1982:Wachstum und Wachstumshormonmangel bei Kindern mit angeborenon Lippen\u2010Kiefer\u2010Gaumen\u2010Spalten. M.D. Theses Ludwig Maximilions University. Munich."},{"key":"e_1_2_1_79_1","article-title":"Letter to the editor: Familial agnathia\u2010holoprosencephaly due to an inherited unbalanced translocation and not autosomal recessive inheritance","volume":"34","author":"Krassikoff N","year":"1982","journal-title":"Am J Med Gent"},{"key":"e_1_2_1_80_1","first-page":"739","article-title":"Sexual precocity with hypothalamic hypopituitarism","volume":"133","author":"LaFranchi SH","year":"1979","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510033131401"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140210"},{"key":"e_1_2_1_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320240321"},{"key":"e_1_2_1_84_1","first-page":"576","article-title":"Pituitary growth hormone insufficiency associated with cleft lip and palate. An embryonal developmental defect","volume":"24","author":"Laron Z","year":"1969","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345710500042401"},{"key":"e_1_2_1_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300202"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290303"},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307388600100102"},{"key":"e_1_2_1_89_1","volume-title":"Anencephaly","author":"Lemire RJ","year":"1978"},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230304"},{"key":"e_1_2_1_91_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/jnen\/13.1.117","article-title":"Malformations of the forebrain","volume":"13","author":"Lichtenstein BW","year":"1954","journal-title":"J Neuropathol Exp Neurol"},{"key":"e_1_2_1_92_1","first-page":"32","article-title":"The cyclops deformity. Case report","volume":"61","author":"Lillard RL","year":"1964","journal-title":"Rocky Mtn Med J"},{"key":"e_1_2_1_93_1","first-page":"25","article-title":"Arhinencephalia: Considerations \u00e1 propos a case diagnosed during life","volume":"67","author":"Lison MP","year":"1967","journal-title":"Acta Neurol Belg"},{"key":"e_1_2_1_94_1","first-page":"887","article-title":"Holoprosencephaly","volume":"128","author":"Lowry RB","year":"1974","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320070216"},{"key":"e_1_2_1_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320030310"},{"key":"e_1_2_1_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1969.tb01853.x"},{"key":"e_1_2_1_98_1","first-page":"129","article-title":"Alcohol embryopathy: Some facts and speculations about pathogenesis","volume":"3","author":"Majewski F","year":"1981","journal-title":"Neurobehav Toxicol Teratol"},{"key":"e_1_2_1_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320110316"},{"key":"e_1_2_1_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160304"},{"key":"e_1_2_1_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420260204"},{"key":"e_1_2_1_102_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2337\/diab.28.4.292","article-title":"Malformations in infants of diabetic mothers occur before the seventh gestational week: Implications for treatment","volume":"28","author":"Mills JL","year":"1979","journal-title":"Diabetes"},{"key":"e_1_2_1_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb00854.x"},{"key":"e_1_2_1_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070905"},{"key":"e_1_2_1_105_1","first-page":"168","article-title":"\u00dcber eine neue mit Cyclopie verkn\u00fcpfte Missbildung des Centralnervensystems","volume":"5","author":"N\u00e1geli O","year":"1897","journal-title":"Roux' Arch Entw Mech"},{"key":"e_1_2_1_106_1","first-page":"157","article-title":"Ring chromosome D(13) associated with multiple congenital malformations","volume":"16","author":"Niebuhr E","year":"1973","journal-title":"Ann Genet (Paris)"},{"key":"e_1_2_1_107_1","volume-title":"Sequential Atlas of Human Congenital Malformations: Observations of Embryos. Fetuses, and Newborns","author":"Nishimura H","year":"1976"},{"key":"e_1_2_1_108_1","series-title":"BD:OAS","first-page":"93","volume-title":"The Clinical Delineation of Birth Defects: Part V, Phenotypic Aspects of Chromosomal Aberrations","author":"Opitz JM","year":"1969"},{"key":"e_1_2_1_109_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/BF00273945","article-title":"The syndrome associated with the partial D\u2010monosomy. Case report and review","volume":"13","author":"Orbeli DJ","year":"1971","journal-title":"Humangenetik"},{"key":"e_1_2_1_110_1","first-page":"134","article-title":"Solitary maxillary incisor","volume":"7","author":"Parker PR","year":"1985","journal-title":"Pediatr Dent"},{"key":"e_1_2_1_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410060408"},{"key":"e_1_2_1_112_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1972.02110140067008"},{"key":"e_1_2_1_113_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1975.02120390017004"},{"key":"e_1_2_1_114_1","unstructured":"PauliRM(1987): Personal communication."},{"key":"e_1_2_1_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230111"},{"key":"e_1_2_1_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320140411"},{"key":"e_1_2_1_117_1","first-page":"240","volume-title":"Development of the Basicranium","author":"Pettersen JC","year":"1976"},{"key":"e_1_2_1_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(79)90033-9"},{"key":"e_1_2_1_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320050214"},{"key":"e_1_2_1_120_1","volume-title":"Pathology of the Fetus and the Newborn","author":"Potter EL","year":"1961"},{"key":"e_1_2_1_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-48757-6"},{"key":"e_1_2_1_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80891-3"},{"key":"e_1_2_1_123_1","unstructured":"ReynoldsJF WaldsteinO(1988):Aprosencephaly: Case report with neuropathology and review of the embryology. 9th Annual David W. Smith Workshop on Malformations and Morphogenesis Oakland California August 3\u20137."},{"key":"e_1_2_1_124_1","series-title":"BD:OAS","first-page":"294","volume-title":"The Clinical Delineation of Birth Defects: Part II, \u201cMalformation Syndromes\u201d","author":"Roach E","year":"1975"},{"key":"e_1_2_1_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091280206"},{"key":"e_1_2_1_126_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.53.12.952"},{"key":"e_1_2_1_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80559-1"},{"key":"e_1_2_1_128_1","unstructured":"RonenGM AndrewsWL(1987):Holoprosencephaly as a possible embryonic alcohol effect. Child Neurology Society Meeting. San Diego October 20."},{"key":"e_1_2_1_129_1","volume-title":"Modern Epidemiology","author":"Rothman KJ","year":"1986"},{"key":"e_1_2_1_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)81141-X"},{"key":"e_1_2_1_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80507-X"},{"key":"e_1_2_1_132_1","first-page":"379","article-title":"Clinical evaluation of two patients with a single maxillary central incisor","volume":"50","author":"Santoro FP","year":"1983","journal-title":"J Dent Child"},{"key":"e_1_2_1_133_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.47.4.193"},{"key":"e_1_2_1_134_1","first-page":"46","article-title":"Cebocephalus (A case report)","volume":"8","author":"Saxena HMK","year":"1971","journal-title":"Indian Pediat"},{"key":"e_1_2_1_135_1","volume-title":"Catalogue of Unbalanced Chromosome Abberations in Man","author":"Schinzel A","year":"1984"},{"key":"e_1_2_1_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80278-4"},{"key":"e_1_2_1_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1983.tb01870.x"},{"key":"e_1_2_1_138_1","first-page":"247","article-title":"Absence of upper central incisor","volume":"104","author":"Scott DC","year":"1958","journal-title":"Br Dent J"},{"key":"e_1_2_1_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(63)90321-9"},{"key":"e_1_2_1_140_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992288402301110"},{"key":"e_1_2_1_141_1","unstructured":"ShiotaK(1978): Personal communication."},{"key":"e_1_2_1_142_1","unstructured":"ShokeirMHK(1979): Personal communication."},{"key":"e_1_2_1_143_1","volume-title":"Holoprosencephaly","author":"Siebert JR","year":"1990"},{"key":"e_1_2_1_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420360302"},{"key":"e_1_2_1_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340103"},{"key":"e_1_2_1_146_1","first-page":"147","article-title":"A case of suspected teratogenic holoprosencephaly","volume":"21","author":"Stabile M","year":"1984","journal-title":"J Med Genet"},{"key":"e_1_2_1_147_1","first-page":"309","article-title":"Embryonic origin of holoprosencephaly: Interrelationships of the developing brain and face","volume":"1","author":"Sulik KK","year":"1982","journal-title":"Scan Electron Microsc"},{"key":"e_1_2_1_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001660303"},{"key":"e_1_2_1_149_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.5.3.227"},{"key":"e_1_2_1_150_1","unstructured":"ThomasIT BuehlerBA(1988):Holoprosencephaly sequence. Intra\u2010familial phenotypic variability. 9th Annual David W. Smith Workshop on Malformations and Morphogenesis Oakland California Aug. 3\u20137."},{"key":"e_1_2_1_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(68)90432-8"},{"key":"e_1_2_1_152_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230088"},{"key":"e_1_2_1_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290308"},{"key":"e_1_2_1_154_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.6.580"},{"key":"e_1_2_1_155_1","first-page":"410","article-title":"Familial short arm deficiency of chromosome 18, concomitant with arhinencephaly and alopecia congenita","volume":"17","author":"Uchida IA","year":"1965","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320300408"},{"key":"e_1_2_1_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1970.tb14669.x"},{"key":"e_1_2_1_158_1","first-page":"321","article-title":"Incisive sup\u00e9rieure unique et d\u00e9ficit en STH","volume":"37","author":"Vanelli M","year":"1980","journal-title":"Arch Fr P\u00e9diatr"},{"key":"e_1_2_1_159_1","volume-title":"Congenital Malformations: Notes and Comments","author":"Warkany J","year":"1971"},{"key":"e_1_2_1_160_1","volume-title":"Mental Retardation and Congenital Malformations of the Central Nervous System","author":"Warkany J","year":"1981"},{"key":"e_1_2_1_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(78)90318-3"},{"key":"e_1_2_1_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320150307"},{"key":"e_1_2_1_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80022-X"},{"key":"e_1_2_1_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000540303"},{"key":"e_1_2_1_165_1","first-page":"320","article-title":"Dorsal cyst malformations. Part I. Clinical study and critical review on the definition of holoprosencephaly","volume":"11","author":"Yokota A","year":"1984","journal-title":"Childs Brain"},{"key":"e_1_2_1_166_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513818609068846"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320340232","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320340232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T01:47:32Z","timestamp":1697939252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320340232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10]]},"references-count":165,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,10]]}},"alternative-id":["10.1002\/ajmg.1320340232"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320340232","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,10]]}}}