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On the basis of these families, autosomal recessive inheritance of the combination WS\u2010HRSD has been postulated. However, a single dominant gene with pleiotropic effects leading to WS and HRSD, with a more severe phenotype in homozygotes, is more plausible. A model of gene action incorporating stochastic effects is compatible with these observations.<\/jats:p>","DOI":"10.1002\/ajmg.1320350119","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:34:51Z","timestamp":1118547291000},"page":"100-104","source":"Crossref","is-referenced-by-count":41,"title":["Waardenburg syndrome and Hirschsprung disease: Evidence for pleiotropic effects of a single dominant gene"],"prefix":"10.1002","volume":"35","author":[{"given":"Judith A.","family":"Badner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aravinda","family":"Chakravarti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80267-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00273330","article-title":"Probable loose linkage between the ABO locus and Waardenburg syndrome type I","volume":"27","author":"Arias S","year":"1975","journal-title":"Humangenetik"},{"key":"e_1_2_1_4_1","first-page":"A44","article-title":"Evidence for dominant gene(s) in Hirschsprung disease","volume":"41","author":"Badner JA","year":"1987","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1963.tb01983.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(82)80124-3"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1985.tb00417.x"},{"key":"e_1_2_1_8_1","series-title":"BD:OAS","first-page":"24","volume-title":"Skeletal Dysplasias","author":"Hall JG","year":"1969"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.24.9.568"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902550309"},{"key":"e_1_2_1_11_1","first-page":"979","article-title":"Genetics, chance, and morphogenesis","volume":"41","author":"Kurnit DM","year":"1987","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000153231"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a109980"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.116.10.1102b"},{"key":"e_1_2_1_15_1","first-page":"764","volume-title":"Mendelian Inheritance in Man, A Catalog of Autosomal Dominant, Autosomal Recessive, and X\u2010Linked Phenotypes","author":"McKusick VA","year":"1988"},{"key":"e_1_2_1_16_1","first-page":"277","article-title":"Sequential tests for the detection of linkage","volume":"7","author":"Morton NE","year":"1955","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_17_1","first-page":"489","article-title":"Analysis of family resemblance. 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