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The 2 techniques have advantages and disadvantages and are demonstrated to be appropriate for routine diagnostic work.<\/jats:p><jats:p>The combined use of both methods may optimize the quality of the chromosome study and minimize the possibility of false\u2010positive and false\u2010negative findings.<\/jats:p>","DOI":"10.1002\/ajmg.1320350208","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:39:08Z","timestamp":1118547548000},"page":"181-183","source":"Crossref","is-referenced-by-count":13,"title":["Direct chromosome preparation and culture using chorionic villi: An evaluation of the two techniques"],"prefix":"10.1002","volume":"35","author":[{"given":"Giuseppe","family":"Simoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Terzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Rossella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1386","article-title":"A method for processing first\u2010trimester chorionic villous biopsies for cytogenetic analysis","volume":"36","author":"Blakemore KJ","year":"1984","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_3_1","first-page":"586","article-title":"Diagnosis of fetal trisomy 21 in first trimester","volume":"1","author":"Brambati B","year":"1983","journal-title":"Lancet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.15.4795"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970060407"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970050407"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070505"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90831-0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1974.tb02090.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970090905"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347309157092"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274761"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-70707-0_29"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000412817","article-title":"First trimester fetal karyotyping by direct method: Technical and diagnostic problems","volume":"15","author":"Terzoli G","year":"1986","journal-title":"Contrib Gynecol Obstet"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-70707-0_24"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00290954"},{"key":"e_1_2_1_17_1","first-page":"576","article-title":"Improved methods of direct and cultured chromosome preparations from chorionic villous samples","volume":"38","author":"Yu M\u2010T","year":"1986","journal-title":"Am J Hum Genet"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320350208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320350208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:28:49Z","timestamp":1698020929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320350208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,2]]}},"alternative-id":["10.1002\/ajmg.1320350208"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320350208","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2]]}}}