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Two adult Bardet\u2010Biedl sibs, a man with hypertension and cardiomegaly and a woman with biliary cirrhosis, and 75 relatives in 5 generations of the extended family were identified. Hospital records for major illnesses, death certificates, and autopsy reports were examined. The frequent observation of obesity, hypertension, diabetes mellitus, and renal disease in first\u2010degree relatives, obligate gene carriers, and other blood relatives raise the possibility that Bardet\u2010Biedl heterozygotes are also predisposed to these disorders.<\/jats:p>","DOI":"10.1002\/ajmg.1320360109","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:48:41Z","timestamp":1118548121000},"page":"37-42","source":"Crossref","is-referenced-by-count":53,"title":["Obesity, hypertension, and renal disease in relatives of Bardet\u2010Biedl syndrome sibs"],"prefix":"10.1002","volume":"36","author":[{"given":"Janet 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