{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T09:57:08Z","timestamp":1698487028441},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":5481,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1990,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Using reverse genetics, a candidate for the sex determining gene from the Y chromosome has recently been cloned. We have used a DNA probe from this gene to assess the presence of this crucial region of the Y chromosome in patients with sexual ambiguity or gonadal dysgenesis. The DNA from 3 cases of gonadal dysgenesis, one complicated by somatic anomalies and mental retardation, reacted normally with this putative sex determining gene. A patient having a small phallus and pseudovaginal, perineoscrotal hypospadias (PPSH) also had normal Y chromosomal DNA. We hypothesize that the defect in sex determination in all 4 cases is most probably subsequent to the primary sex determining switch.<\/jats:p>","DOI":"10.1002\/ajmg.1320360218","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:10:21Z","timestamp":1118545821000},"page":"232-236","source":"Crossref","is-referenced-by-count":4,"title":["Use of a probe for the putative sex determining gene, Zinc finger Y, in the study of patients with ambiguous genitalia and XY gonadal dysgenesis"],"prefix":"10.1002","volume":"36","author":[{"given":"Robert P.","family":"Erickson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Verga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majed","family":"Dasouki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/320170a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.7.1991"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260110"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1986.051.01.030"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90381-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03844.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.567843"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90446-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/14.16.6489"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80242-1"},{"issue":"1","key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1242\/dev.101.Supplement.151","article-title":"Hypothesis: A Y\u2010chromosomal gene causes gonadoblastoma in dysgenetic gonads","volume":"101","author":"Page DC","year":"1987","journal-title":"Development"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90595-2"},{"key":"e_1_2_1_14_1","first-page":"371","article-title":"Les anomalies de d\u00e9veloppement du sacrum","volume":"35","author":"Pouzet F","year":"1938","journal-title":"Lyon Chir"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.15.6159"},{"key":"e_1_2_1_16_1","first-page":"45","article-title":"L'agenes\u00ede sacrococcygienne familiale","volume":"22","author":"Robert JM","year":"1974","journal-title":"J Genet Hum"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278350"},{"key":"e_1_2_1_18_1","first-page":"455","article-title":"Malignant potential of the dysgenetic gonad. 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