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We observed that skin fibroblasts synthesized two populations of pro\u221d\ufe01I(I) chains of type I procollagen; one population was normal, while the other population had excessive post\u2010translational modification. The thermal stability of helices containing the overmodified chains was reduced 1\u20102\u00b0C. Most significantly, the cells cultured from chorionic villi produced type I collagen chains with the same electrophoretic abnormalities as the skin collagen. This suggests that chorionic villus sampling (CVS) is a means of prenatal diagnosis for families with a previous type II or type IV OI infant.<\/jats:p>","DOI":"10.1002\/ajmg.1320360223","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:10:21Z","timestamp":1118545821000},"page":"258-264","source":"Crossref","is-referenced-by-count":5,"title":["Analysis Of cultured chorionic villi in a case of osteogenesis imperfecta type II: Implications for prenatal diagnosis"],"prefix":"10.1002","volume":"36","author":[{"given":"Dorothy K.","family":"Grange","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Beth","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan 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