{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:10:16Z","timestamp":1757704216823},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":5451,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Five of 13 patients with microphthalmia or clinical anophthalmia studied in an institution of 650 mentally retarded adults had hypogonadotropic hypogonadism. Four males had low testosterone levels and sexual infantilism, manifesting as micropenis with small testes or cryptorchidism. One female had primary amenorrhea. All 5 patients had low gonadotropin levels, confirming a hypothalamic or pituitary basis for their hypogonadism. Thyroxin, thyroid stimulating hormone, prolactin, and A.M. cortisol were also measured and were normal. All patients with hypogonadotropic hypogonadism were chromosomally normal and had variable central nervous system defects, suggesting that they comprise a heterogeneous group of disorders. Microphthalmia or anophthalmia in a mentally retarded patient is associated with hypogonadotropic hypogonadism.<\/jats:p>","DOI":"10.1002\/ajmg.1320360307","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:48:30Z","timestamp":1118537310000},"page":"285-287","source":"Crossref","is-referenced-by-count":8,"title":["Hypogonadotropic hypogonadism in mentally retarded adults with microphthalmia and clinical anophthalmia"],"prefix":"10.1002","volume":"36","author":[{"given":"Laura Davis","family":"Keppen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Brodsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith M.","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann R.","family":"Poindexter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"64","article-title":"Anophthalmia, microcephaly, hypotonia, hypogonadism, failure to thrive, and developmental delay","volume":"1","author":"Al Fryh AR","year":"1987","journal-title":"Dysmorphol Clin Genet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5918.533"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-198402410-00008"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1986.tb01258.x"},{"key":"e_1_2_1_6_1","first-page":"415","volume-title":"System of Ophthalmology","author":"Duke\u2010Elder S","year":"1963"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816818209031458"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80513-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1988.tb04040.x"},{"key":"e_1_2_1_10_1","first-page":"203","article-title":"The genetic aspects of primary eunuchoidism","volume":"48","author":"Kallmann FJ","year":"1944","journal-title":"Am J Ment Defic"},{"key":"e_1_2_1_11_1","first-page":"249","volume-title":"Clinical Pediatrics and Adolescent Endocrinology","author":"Kaplan SA","year":"1982"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0002-9378(77)90750-5","article-title":"Microphthalmia and olfactogenital dysplasias: A possible relationship","volume":"129","author":"Kemmann E","year":"1977","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_13_1","first-page":"382","volume-title":"The Developing Human","author":"Moore KL","year":"1988"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80454-4"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816818509004125"},{"key":"e_1_2_1_16_1","first-page":"320","volume-title":"Langman's Medical Embryology","author":"Sadler TW","year":"1985"},{"key":"e_1_2_1_17_1","series-title":"BD:OAS","first-page":"136","volume-title":"The Eye","author":"Warburg M","year":"1971"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00139580"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816818309007809"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320150307"},{"key":"e_1_2_1_21_1","first-page":"233","volume-title":"Williams Textbook of Endocrinology","author":"Wilson JD","year":"1985"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320360307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320360307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T04:30:40Z","timestamp":1698035440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320360307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,7]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,7]]}},"alternative-id":["10.1002\/ajmg.1320360307"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320360307","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,7]]}}}