{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:52:42Z","timestamp":1787647962357,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":5451,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A Pakistani kindred comprising 7 generations contained 7 men and 2 women with fibular hypoplasia and complex brachydactyly (syn: Du Pan syndrome). Analysis of the pedigree is strongly suggestive of autosomal recessive inheritance. The average inbreeding coefficient (F) for the affected persons was found to be significantly greater than that for unaffected persons in the pedigree and consanguineous loops could account for all affected persons being homozygous for the abnormal allele.<\/jats:p>","DOI":"10.1002\/ajmg.1320360309","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:48:30Z","timestamp":1118537310000},"page":"292-296","source":"Crossref","is-referenced-by-count":18,"title":["Fibular hypoplasia and complex brachydactyly (Du Pan Syndrome) in an inbred Pakistani kindred"],"prefix":"10.1002","volume":"36","author":[{"given":"Mahmud","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Wahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayedul","family":"Haque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"227","article-title":"Absence cong\u00e9nitale du p\u00e9ron\u00e9 sans d\u00e9formation du tibia. Curieuses d\u00e9formations cong\u00e9nitales des mains","volume":"11","author":"Du Pan CM","year":"1924","journal-title":"Rev Orthop"},{"key":"e_1_2_1_3_1","first-page":"300","article-title":"Chondrodysplasie","volume":"2","author":"Grebe H","year":"1955","journal-title":"Anal Genet"},{"key":"e_1_2_1_4_1","first-page":"297","article-title":"Chondrodysplasie","volume":"2","author":"Grebe H","year":"1955","journal-title":"Anal Genet"},{"key":"e_1_2_1_5_1","first-page":"304","article-title":"Chondrodysplasie","volume":"2","author":"Grebe H","year":"1955","journal-title":"Anal Genet"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00284447"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00283684"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.9.2.174"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0001566000009557"},{"key":"e_1_2_1_10_1","volume-title":"Introduction to Biostatistics","author":"Sokal RS","year":"1973"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/279872"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320360309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320360309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T04:30:44Z","timestamp":1698035444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320360309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,7]]}},"alternative-id":["10.1002\/ajmg.1320360309"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320360309","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,7]]}}}