{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:05:55Z","timestamp":1790193955761,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,5]],"date-time":"2005-06-05T00:00:00Z","timestamp":1117929600000},"content-version":"vor","delay-in-days":5422,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Prader\u2010Willi syndrome (PWS) is characterized by short stature, mild mental retardation, and a characteristic face. Approximately 75% of all patients have a del (15q). Ceph\u2010alometric roentgenograms of 20 PWS patients of both sexes (12 adults, 8 children, age 4.5\u201350.0 years) were analyzed to determine if the facial appearance is reflected in changes in the bony architecture, a characteristic which might be useful in diagnosis and\/or dental treatment of these individuals. PWS subjects were compared with chronologic age and sex\u2010matched control individuals derived from the Denver Growth study using 52 point computer analyzed lateral head\u2010plate tracings performed by the same individual (RS). The mean Z\u2010score differences for mandibular and maxillary total length, ramus height, mandibular corpus length, posterior facial height, and mid\u2010facial height were all significantly smaller in &gt;65% of the PWS subjects; this was more evident in the PWS children. The Z\u2010score difference for posterior cranial base was very large in most PWS adults and children whereas lower facial height was small or normal in all subjects. No statistical difference in mean Z\u2010score measurements was found for all these measures in PWS subjects with or without the 15q chromosome deletion. The overall small bony structures contrast with the relatively large soft tissue draping seen especially in obese adults. The data suggest that a characteristic bony model might be created for PWS which could be of use in diagnosis and in the treatment of PWS patients by their orthodontist.<\/jats:p>","DOI":"10.1002\/ajmg.1320360423","type":"journal-article","created":{"date-parts":[[2005,9,6]],"date-time":"2005-09-06T13:37:15Z","timestamp":1126013835000},"page":"484-487","source":"Crossref","is-referenced-by-count":15,"title":["Cephalometric analysis of the Prader\u2010Willi syndrome"],"prefix":"10.1002","volume":"36","author":[{"given":"Robert","family":"Schaedel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne B.","family":"Cassidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"269","article-title":"Cephalometrics for orthognathic surgery","volume":"36","author":"Burstone CJ","year":"1978","journal-title":"J Oral Surg"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260224"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0045-9380(84)90043-4"},{"key":"e_1_2_1_5_1","volume-title":"Human Growth and Development","author":"McCammon RW","year":"1970"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330740405"},{"key":"e_1_2_1_7_1","first-page":"499","volume-title":"Factors and Mechanisms Influencing Bone Growth","author":"Poole AE","year":"1982"},{"key":"e_1_2_1_8_1","first-page":"1260","article-title":"Ein syndrom von adipositos, kleinwuchs, kryporchismus und oligophrenie nech myotonicertigem zustand in neugeborenalter","volume":"86","author":"Prader A","year":"1956","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_1_9_1","first-page":"44","volume-title":"A Synopsis of Craniofacial Growth","author":"Ranly DM","year":"1988"},{"key":"e_1_2_1_10_1","first-page":"588","article-title":"Syndrome of hypomentia\u2010hypogonadism\u2010obesity (HHHO) or Prader\u2010Willi syndrome","volume":"115","author":"Zellweger H","year":"1968","journal-title":"Am J Dis Child"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320360423","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320360423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T14:23:22Z","timestamp":1697984602000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320360423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,8]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,8]]}},"alternative-id":["10.1002\/ajmg.1320360423"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320360423","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,8]]}}}