{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:14:44Z","timestamp":1787170484568,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,8]],"date-time":"2005-06-08T00:00:00Z","timestamp":1118188800000},"content-version":"vor","delay-in-days":5394,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The proposita presented at birth with multiple congenital anomalies including craniofacial anomalies, bilateral cleft lip and palate, abnormalities of the urogenital system, talipes equinovarus, and the DiGeorge sequence. Cytogenetic investigation showed a 46,XX,\u2010 22,+der(9)t(9;22)(q22;q11.2) karyotype. The mother, maternal uncle, and maternal grandmother of the infant are carriers of a reciprocal balanced translocation involving chromosomes 9 and 22 at regions q22 and q11.2, respectively. The unbalanced karyotype seen in the proposita arose due to an adjacent\u20102 disjunction of the quadrivalent in the mother. Prenatal diagnosis of the second pregnancy of this woman showed a similar karyotype. Review of the literature shows that adjacent\u20102 disjunction may occur preferentially when certain chromosomes are involved in translocations.<\/jats:p>","DOI":"10.1002\/ajmg.1320370121","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T23:51:50Z","timestamp":1118533910000},"page":"92-96","source":"Crossref","is-referenced-by-count":16,"title":["Adjacent\u20102 disjunction of a maternal t(9;22) leading to duplication 9pter\u2192q22 and deficiency of 22pter\u2192q11.2"],"prefix":"10.1002","volume":"37","author":[{"given":"Enik\u00f6 K.","family":"Pivnick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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