{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:33:37Z","timestamp":1758926017947},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,8]],"date-time":"2005-06-08T00:00:00Z","timestamp":1118188800000},"content-version":"vor","delay-in-days":5394,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maternal serum pregnancy specific beta\u20101 glycoprotein (SP\u20101) levels in the second trimester may be predictive of Down syndrome (DS). An enzyme immunoassay was used to measure SP\u20101 sera from 46 DS pregnancies and 117 normal control women matched for maternal age, gestational age, and length of storage. In the normal control samples, there were slight correlations between the SP\u20101 concentration and maternal age. The maternal serum SP\u20101 levels increased with each week of gestation from 15 to 20 weeks. All but one of the DS sera had SP\u20101 levels greater than the normal median. Using a cutoff of 2.8 multiples of the median (MoM), 15.2% of the DS pregnancies were detected with a false\u2010positive rate of 4.3%. A combinational logistic regression analysis of maternal age and pregnancy related serum proteins will detect additional DS pregnancies and decrease the false\u2010positive rate. The combination of maternal age and SP\u20101 detected 33 (71.7%) of Down syndrome pregnancies. The addition of maternal serum\u03b1\u2010fetoprotein (AFP) and human chorionic gonadotropin (hCG) levels allowed for the detection of 36 (78.3%) of the DS pregnancies with a decrease in the false\u2010positive rate to 3.4%. The measurement of other serum constituents in conjunction with AFP appears to be a valuable addition to current screening programs, as this can increase the proportion of DS cases detected prenatally.<\/jats:p>","DOI":"10.1002\/ajmg.1320370127","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:51:50Z","timestamp":1118548310000},"page":"114-118","source":"Crossref","is-referenced-by-count":12,"title":["Second trimester maternal serum pregnancy specific beta\u20101 glycoprotein (SP\u20101) levels in normal and down syndrome pregnancies"],"prefix":"10.1002","volume":"37","author":[{"given":"Elizabeth","family":"Petrocik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Robert","family":"Wassman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Jack","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnn C.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781412984744"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1980.tb04585.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00451454"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","unstructured":"BartelsI ThickM BogartMH(1990): Matenal serum hCG and SP1 in pregnancies with fetal aneuploidy.Am J Med Genet(in press).","DOI":"10.1002\/ajmg.1320370220"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070904"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970090602"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06601.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92389-4"},{"key":"e_1_2_1_10_1","volume-title":"Comparison of enzyme\u2010immunoassays for SP1 and AFP with other immunological methods","author":"Dati F","year":"1982"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90655-1"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1037187"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070406"},{"key":"e_1_2_1_14_1","first-page":"331","article-title":"Specific and sensitive determination of pregnancy\u2010specific B1\u2010glycoprotein by radioimmunoassay","volume":"1","author":"Grudzinskas G","year":"1977","journal-title":"Lancet"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01927624"},{"key":"e_1_2_1_16_1","volume-title":"Introduction to Probability and Statistics","author":"Mendenhall W","year":"1979"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90530-1"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90449-8"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90657-1"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90628-4"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6653.883"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06602.x"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320370127","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320370127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T02:50:21Z","timestamp":1698029421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320370127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["10.1002\/ajmg.1320370127"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320370127","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}