{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:00:03Z","timestamp":1791327603024,"version":"4.3.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,8]],"date-time":"2005-06-08T00:00:00Z","timestamp":1118188800000},"content-version":"vor","delay-in-days":5394,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report on an Arabic sibship originating from Morocco in which four children manifest an undiagnosed sublethal multiple congenital anomaly\/mental retardation (MCA\/MR) syndrome of intrauterine growth retardation (IUGR), microcephaly, large soft pinnae, telecanthus or true hypertelorism with squint, flat face, unusual hooked nose, very narrow mouth, retrognathia, and extremely severe neurologic impairment. One child was stillborn. Three others died in a cachectic state during their second year. One child had a severe cerebral malformation compatible with semilobar holoprosencephaly. Other inconstant manifestations are anterior chamber cleavage defect, preaxial polydactyly of feet, interventricular septal defect, and atresia of the external auditory meatus. Autosomal recessive inheritance is likely.<\/jats:p>","DOI":"10.1002\/ajmg.1320370128","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:51:50Z","timestamp":1118548310000},"page":"119-123","source":"Crossref","is-referenced-by-count":21,"title":["Lambotte syndrome: Microcephaly, holoprosencephaly, intrauterine growth retardation, facial anomalies, and early lethality\u2014A new sublethal multiple congenital anomaly\/mental retardation syndrome in four sibs"],"prefix":"10.1002","volume":"37","author":[{"given":"A.","family":"Verloes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Dodinval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Beco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bonnivert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lambotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1542\/peds.68.2.235","article-title":"New syndrome in three affected siblings","volume":"68","author":"Crane JP","year":"1981","journal-title":"Pediatrics"},{"issue":"5","key":"e_1_2_1_3_1","first-page":"107","article-title":"A new familial syndrome with craniofacial anomalies, osseous defects and mental retardation","volume":"11","author":"Grix A","year":"1975","journal-title":"BD OAS"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1542\/peds.53.3.425","article-title":"Typus Edinburgensis?","volume":"53","author":"Habel A","year":"1974","journal-title":"Pediatrics"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1985.tb00395.x"},{"key":"e_1_2_1_6_1","unstructured":"LambotteC ThibautA MossayC KeutgenJ(1978)Malformations c\u00e9r\u00e9brales avec microc\u00e9phalie dysmorphies retard majeur du d\u00e9veloppement staturopond\u00e9ral et psychomoteur: Nouveau syndrome h\u00e9r\u00e9ditaire autosomique r\u00e9cessif?Abstracts of the Meeting from the European Club of Genetic Counselling La Baule France 15\u201316."},{"key":"e_1_2_1_7_1","first-page":"57","article-title":"Nanisme familial cong\u00e9nital avec dysplasie c\u00e9phalo\u2010squelettique (syndrome de Taybi\u2010Linder)","volume":"41","author":"Lavollay B","year":"1985","journal-title":"Arch Fr P\u00e9diatr"},{"key":"e_1_2_1_8_1","first-page":"253","article-title":"La ph\u00e9nocopie de la trisomie 18: Une maladie autosomique r\u00e9cessive?","volume":"38","author":"Le Marec B","year":"1981","journal-title":"Arch Fr P\u00e9diatr"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/89.2.275"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.22.1.73"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320310105"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320370128","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320370128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T02:50:26Z","timestamp":1698029426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320370128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["10.1002\/ajmg.1320370128"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320370128","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}