{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:18:27Z","timestamp":1790979507978,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T00:00:00Z","timestamp":1118016000000},"content-version":"vor","delay-in-days":5301,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An 18\u2010year\u2010old Caucasian woman has been followed since age 12 years for Ehlers\u2010Danlos syndrome (EDS) with easy bruisability and \u201ccigarette paper scars.\u201d Her chief complaint at age 17 years was tooth mobility, especially in the anterior mandible, necessitating the removal of the four incisors. Initial biochemical analysis of cultured skin fibroblasts indicated the presence of pepsin\u2010sensitive type III collagen. Subsequent analysis of cultured skin fibroblasts by the same laboratory and another laboratory found no abnormality in the type III collagen with or without protease treatment. This is in distinction to the finding of abnormal type III collagen in the only two reported patients with EDS and early\u2010onset periodontitis who have had collagen analyses. One of them was diagnosed as EDS type IV and the other as EDS type VIII, although the defects of type III collagen were consistent with EDS type IV. The defect in type III collagen in some patients with early periodontitis and the considerable overlap of the clinical manifestations of EDS types IV and VIII point out the need for further studies of collagen formation and maturation in any patient who has early periodontitis and who has been classified with EDS type IV or VIII.<\/jats:p>","DOI":"10.1002\/ajmg.1320370408","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:56:23Z","timestamp":1118548583000},"page":"465-470","source":"Crossref","is-referenced-by-count":50,"title":["Phenotypic overlap of Ehlers\u2010Danlos syndrome types IV and VIII"],"prefix":"10.1002","volume":"37","author":[{"given":"James K.","family":"Hartsfield Jr.","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris G.","family":"Kousseff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290316"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340114"},{"key":"e_1_2_1_4_1","first-page":"836","volume-title":"Principles and Practice of Medical Genetics","author":"Byers PH","year":"1983"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00273196"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb01012.x"},{"issue":"1","key":"e_1_2_1_7_1","first-page":"99A","article-title":"Ehlers\u2010Danlos syndrome, type VIII, abstracted","volume":"28","author":"Hollister DW","year":"1980","journal-title":"Clin Res"},{"key":"e_1_2_1_8_1","first-page":"422","article-title":"Ehlers\u2010Danlos [ED] type VIII skin has a reduced proportion of collagen type III, abstracted","volume":"76","author":"Lapiere CHM","year":"1981","journal-title":"J Invest Dermatol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4804291"},{"key":"e_1_2_1_10_1","first-page":"358","volume-title":"Heritable disorders of Connective Tissue","author":"McKusick VA","year":"1972"},{"key":"e_1_2_1_11_1","volume-title":"Mendelian Inheritance in Man","author":"McKusick VA","year":"1990"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)45304-5"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(83)80047-8"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70095-1"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.9.1016"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340105"},{"key":"e_1_2_1_17_1","volume-title":"New Syndromes","author":"Stewart RE","year":"1977"},{"issue":"3","key":"e_1_2_1_17_2","first-page":"85","article-title":"National Foundation\u2010March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12494614"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278783"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320370408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320370408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T16:32:53Z","timestamp":1697992373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320370408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["10.1002\/ajmg.1320370408"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320370408","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}