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Evidence from the histories of the patients and their relatives combined with other reports of cases of cooccurrence of TS and autism provides support for the hypothesis that TS may be responsible forcases of coocurrence of the disorders, contributes significantly to the etiological heterogeneity of autistic disorder and that a portion of cases of autism may actually be a result of homozygosity for the TS gene. In addition, the presence of affective disorders and autistic\u2010like syndromes or mild disturbances of social relatedness in some of the pedigrees suggests the hypothesis that TS may be responsible for a subgroup of families with cooccurring affective and autistic disorders and for some cases of familial aggregation of autism\u2013PDD.<\/jats:p>","DOI":"10.1002\/ajmg.1320390212","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:21:32Z","timestamp":1118546492000},"page":"173-179","source":"Crossref","is-referenced-by-count":55,"title":["Tourette syndrome and autistic disorder: A significant relationship"],"prefix":"10.1002","volume":"39","author":[{"given":"Jeffrey","family":"Sverd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00004703-198312000-00012","article-title":"Coincident infantile autism and Tourette syndrome: A case report","volume":"4","author":"Barabas G","year":"1983","journal-title":"J Dev Behav Pediatr"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01538054"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.146.6.664"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.152.3.377"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1988.tb00735.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050230014005"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/070674378403000115","article-title":"Tourette syndrome, atypical pervasive developmental disorder and Ganser syndrome in a 15\u2010year\u2010old visually impaired, mentally retarded boy","volume":"30","author":"Burd L","year":"1985","journal-title":"Can J Psychiat"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198703000-00006"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1989.tb00775.x"},{"key":"e_1_2_1_11_1","first-page":"20","volume-title":"Handbook of Autism and Pervasive Developmental Disorders","author":"Cohen DJ","year":"1987"},{"key":"e_1_2_1_12_1","first-page":"804","article-title":"A controlled study of Tourette syndrome. 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