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Pregnancy was complicated initially by polyhydramnios in both amniotic sacs and premature uterine contraction. After administration of indomethacin and terbutaline from 16 to 30 weeks' gestation, serial prenatal ultrasound examinations ultimately showed oligohydramnios in twin B and resolution of polyhydramnios in twin A. On day 5 twin B developed hematuria, hypertension, renal failure, hyponatremia, hyperkalemia, metabolic acidosis, sodium wasting and severe, transient inability to excrete potassium. Renal sonography showed enlarged, hyperechoic kidneys with almost no corticomedullary differentiation. Renal biopsy revealed immature glomeruli, dilated Bowman's spaces, dilated tubules, and interstitial fibrosis. The liver was histologically normal.<\/jats:p><jats:p>Indomethacin may induce oligohydramnios and transient renal insufficiency in humans and renal dysgenesis in fetal monkeys; it might have induced the abnormalities in this patient.<\/jats:p>","DOI":"10.1002\/ajmg.1320390304","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:23:20Z","timestamp":1118546600000},"page":"252-257","source":"Crossref","is-referenced-by-count":26,"title":["Renal dysgenesis in a monozygotic twin: Association with in utero exposure to indomethacin"],"prefix":"10.1002","volume":"39","author":[{"given":"Irene","family":"Restaino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard S.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrietta Kotlus","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camillus","family":"Witzleben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320160110"},{"key":"e_1_2_1_3_1","first-page":"213","article-title":"Developmental abnormalities of the renal parenchyma\u2014renal hypoplasia and dysplasia","volume":"3","author":"Bernstein J","year":"1968","journal-title":"Pathol Annu"},{"key":"e_1_2_1_4_1","first-page":"1760","volume-title":"Campbell's Urology","author":"Bernstein J","year":"1986"},{"key":"e_1_2_1_5_1","first-page":"27","volume-title":"Genetics of Kidney Disorders","author":"Bernstein J","year":"1989"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80244-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90008-0"},{"key":"e_1_2_1_8_1","first-page":"287","article-title":"Reins polykystiques a transmission dominante chez un nourrisson","volume":"38","author":"Freycon M\u2010T","year":"1982","journal-title":"Pediatrie"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00859626"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999450"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000242597"},{"key":"e_1_2_1_12_1","first-page":"1","volume-title":"Advances in Nephrology","author":"Grunfeld J\u2010P","year":"1985"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198811000-00021"},{"key":"e_1_2_1_14_1","first-page":"205","article-title":"A propos dune famile asscoiant des cas de polykystose renale de type juvenile et de type adulte","volume":"14","author":"Hoeffel J\u2010C","year":"1971","journal-title":"Ann Radiol"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290323"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80735-8"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00859625"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340423"},{"key":"e_1_2_1_19_1","first-page":"462","article-title":"Glomerulocystic kidney","volume":"101","author":"Krous H","year":"1977","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_20_1","first-page":"536","article-title":"Glomerulocystic kidney","volume":"133","author":"McAlister WH","year":"1979","journal-title":"Am J Radiol"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(86)80012-6"},{"key":"e_1_2_1_22_1","first-page":"283","article-title":"Effects of indomethacin on labor, fetal oxygentation, and fetal development in rhesus monkeys","volume":"4","author":"Novy MJ","year":"1978","journal-title":"Adv Prostaglandin Thromboxane Leukotriene Res"},{"key":"e_1_2_1_23_1","first-page":"241","article-title":"The pathogenesis of the first and second branchial arch syndrome","volume":"89","author":"Poswillo D","year":"1973","journal-title":"J Pediatr"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1542\/peds.70.6.971","article-title":"Autosomal dominant polycystic kidney disease in the neonatal period: Association with a cerebral arteriovenous malformation","volume":"70","author":"Proesmans W","year":"1982","journal-title":"Pediatrics"},{"key":"e_1_2_1_25_1","first-page":"271","volume-title":"Pediatric Nephrology","author":"Resnick J","year":"1987"},{"key":"e_1_2_1_26_1","first-page":"263","article-title":"Familial hypoplastic glomerulocystic kidney","volume":"18","author":"Rizzoni G","year":"1982","journal-title":"A new entity? 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