{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:16:59Z","timestamp":1771658219803,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T00:00:00Z","timestamp":1118016000000},"content-version":"vor","delay-in-days":5119,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b1\u2010Thalassemia hydrops fetalis is a common disorder in Taiwan. The condition causes perinatal death and many maternal obstetrical complications. In order to determine the molecular defects of this condition in Chinese, 87 unrelated families with this disorder were collected in the past 4 years. The molecular defects were studied by Southern blotting and DNA hybridization with \u03c6\u03b61\u2010globin gene and LO (a 0.4 kb BamHI\/EcoRI fragment in the 5\u2032 flanking region of the \u03b62\u2010globin gene) probes. Eighty\u2010one (93.1%) fetuses had homozygous Southeast Asian deletion (\u2013 \u2013<jats:sup>SEA<\/jats:sup>\/\u2013 \u2013<jats:sup>SEA<\/jats:sup>). Five (5.7%) fetuses were compound heterozygotes for the Southeast Asian deletion and Thailand deletion (\u2013 \u2013<jats:sup>SEA<\/jats:sup>\/\u2013 \u2013<jats:sup>THAI<\/jats:sup>). The remaining fetus was a compound heterozygote for the Southeast Asian deletion and an uncharacterized nondeletional defect (\u2013 \u2013<jats:sup>SEA<\/jats:sup>\/(\u03b1\u03b1)Th). The molecular defects of \u03b1\u2010thalassemia hydrops fetalis in Chinese are heterogeneous. This fact has important implications for genetic counseling and prenatal diagnosis.<\/jats:p>","DOI":"10.1002\/ajmg.1320390314","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:23:20Z","timestamp":1118546600000},"page":"317-320","source":"Crossref","is-referenced-by-count":58,"title":["Molecular characterization of severe \u03b1\u2010Thalassemias causing hydrops fetalis in Taiwan"],"prefix":"10.1002","volume":"39","author":[{"given":"Tsang\u2010Ming","family":"Ko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fon\u2010Jou","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pi\u2010Mei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu\u2010Yao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V66.1.224.224"},{"key":"e_1_2_1_3_1","first-page":"321","article-title":"Antenatal detection of hydrops fetalis by sonography: hemoglobin Bart's as a major etiological factor in Taiwan","volume":"5","author":"Chen HY","year":"1984","journal-title":"J Ecog Med Ultrason"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(83)90418-9"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb02469.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.16.5022"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/14.4.1903"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1182\/blood.V73.5.1081.1081","article-title":"A review of the molecular genetics of the human \u03b1\u2010globin gene cluster","volume":"73","author":"Higgs DR","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90453-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(87)80343-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970091007"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90240-8"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb01447.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/321785a0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198602000-00004"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90289-3"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.6.3586"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90311-7"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(77)90052-3"},{"key":"e_1_2_1_20_1","first-page":"106","article-title":"Sonographic evaluation of hydrops fetalis","volume":"74","author":"Saltzman DH","year":"1989","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1986.tb01734.x"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970060203"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/j.1460-2075.1984.tb02051.x","article-title":"The molecular basis of \u03b1\u2010thalassemia in Thailand","volume":"3","author":"Winichagoon P","year":"1984","journal-title":"EMBO J"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320390314","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320390314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T02:40:23Z","timestamp":1698028823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320390314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,6]]}},"alternative-id":["10.1002\/ajmg.1320390314"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320390314","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,6]]}}}