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Supportive evidence was radioresistant DNA synthesis in fibroblasts and radiation hypersensitivity of short\u2010term lymphocyte cultures. Follow\u2010up for nearly 4 years showed largely normal development, and no signs of telangiectasia, ataxia, or immunodeficiency. Serum AFP levels turned from elevated at age 5 months to normal at age 2 years. We propose that our patient belongs to the expanding category of \u201cAT\u2010related\u201d genetic disorders, probably to the Nijmegen breakage syndrome.<\/jats:p>","DOI":"10.1002\/ajmg.1320400109","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:12:40Z","timestamp":1118549560000},"page":"44-50","source":"Crossref","is-referenced-by-count":43,"title":["Chromosome instability and X\u2010ray hypersensitivity in a microcephalic and growth\u2010retarded child"],"prefix":"10.1002","volume":"40","author":[{"given":"Gotthold","family":"Barbi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques M. J. C.","family":"Scheres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlev","family":"Schindler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob D. F. 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