{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:27:28Z","timestamp":1698125248053},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T00:00:00Z","timestamp":1118016000000},"content-version":"vor","delay-in-days":5089,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The metacarpophalangeal pattern profile (MCPP) analysis is a widely used method of standardization of bone length measurements to quantify congenital skeletal dysplasia of the hands.<\/jats:p><jats:p>A main source of inaccuracy is the prominent scatter in the values of the standard deviation (S.D.) of the reference length, which is used in the calculation of the standardized values (Z\u2010scores).<\/jats:p><jats:p>Other sources of error, especially when bone length measurements of younger children are evaluated, are the rather large variability in the age of appearance of the epiphyses of the different bones, and the use of tabulated reference data which are available only at one\u2010year intervals.<\/jats:p><jats:p>We have devised another method of standardization of bone length measurements, by calculating the Q\u2010score. Its advantages are that no S.D. values are needed and that more accurate results are obtained. Moreover the interpretation of the Q\u2010scores is more straightforward than the interpretation of the Z\u2010scores. Q\u2010scores for 3 patients with Sotos syndrome are presented.<\/jats:p><jats:p>Use of the MCPP in the form of the Q\u2010score, will probably make it an even stronger tool than before.<\/jats:p>","DOI":"10.1002\/ajmg.1320400123","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:12:40Z","timestamp":1118549560000},"page":"107-114","source":"Crossref","is-referenced-by-count":6,"title":["Metacarpophalangeal pattern profiles: Q\u2010score for ages from birth to 7 years"],"prefix":"10.1002","volume":"40","author":[{"given":"Piet F.","family":"Dijkstra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk W.","family":"Venema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1055862"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1052786"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/105.2.375"},{"key":"e_1_2_1_5_1","first-page":"117","article-title":"Metrische auswertung der kurzen R\u00f6hrenknochen der Hand von der Geburt bis zum Ende der Pubert\u00e4t: L\u00e4ngenmasse","volume":"13","author":"Gefferth K","year":"1972","journal-title":"Acta Paediatr Acad Sci Hung"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/104.1.1"},{"key":"e_1_2_1_7_1","first-page":"34","volume-title":"The Hand in Radiologic Diagnosis","author":"Poznanski AK","year":"1984"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320400123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320400123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T08:11:55Z","timestamp":1698048715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320400123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1002\/ajmg.1320400123"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320400123","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}