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Her infant had an alobar holoprosencephaly associated with a median cleft lip, ocular hypotelorism, and a flat nose. The other infants had semilobar holoprosencephaly and hydrocephalus. These latter 2 infants did not show the characteristic facies of the fetal alcohol syndrome. G\u2010band chromosome studies were normal in all 3 infants. The association of holoprosencephaly with alcohol exposure during pregnancy in humans has been mentioned only briefly, although this malformation has been induced by alcohol in animals. These 3 infants may support the hypothesis that acute or subacute heavy alcohol exposure early in pregnancy could lead to holoprosencephaly without the necessity of a chronic alcohol exposure and without necessarily causing the typical facial findings of the fetal alcohol syndrome.<\/jats:p>","DOI":"10.1002\/ajmg.1320400206","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:27:22Z","timestamp":1118546842000},"page":"151-154","source":"Crossref","is-referenced-by-count":69,"title":["Holoprosencephaly as a possible embryonic alcohol effect"],"prefix":"10.1002","volume":"40","author":[{"given":"Gabriel M.","family":"Ronen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne L.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2669-4"},{"key":"e_1_2_1_3_1","first-page":"178","article-title":"Holoprosencephaly in a cocaine exposed infant","volume":"47","author":"Bader PI","year":"1990","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80185-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90791-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80645-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320280110"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(87)90301-3"},{"key":"e_1_2_1_9_1","first-page":"647","article-title":"Deux cas de cyclopie","volume":"23","author":"Castel Y","year":"1976","journal-title":"Ann Pediatr (Paris)"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80349-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420400304"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340232"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80129-7"},{"key":"e_1_2_1_14_1","first-page":"321","article-title":"Genetic influences on brain growth restriction induced by development exposure to alcohol","volume":"10","author":"Goodlett CR","year":"1989","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_15_1","first-page":"391","article-title":"Trisomy D in cyclops. 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