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Both sequences share phenotypic manifestations, such as arthrogryposis, short umbilical cord, and lung hypoplasia, in relation to decreased intrauterine fetal motility. Other characteristic manifestations found in OS, such as Potter face, and redundant skin, are produced by fetal compression. On the other hand, growth retardation, craniofacial anomalies, micrognathia, long bone hypoplasia, and polyhydramnios found in FADS could be related to intrauterine muscular weakness.<\/jats:p>","DOI":"10.1002\/ajmg.1320400307","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:24:13Z","timestamp":1118550253000},"page":"284-289","source":"Crossref","is-referenced-by-count":42,"title":["Pathogenetic mechanisms of fetal akinesia deformation sequence and oligohydramnios sequence"],"prefix":"10.1002","volume":"40","author":[{"given":"Jos\u00e9 Ignacio","family":"Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320160211"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320170411"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320190408"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290110"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020105"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)90399-9"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092190104"},{"key":"e_1_2_1_9_1","first-page":"102","volume-title":"Smith's Recognizable Patterns of Human Deformation","author":"Graham JM","year":"1988"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80640-8"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1052435"},{"key":"e_1_2_1_12_1","first-page":"44","article-title":"Genetic aspects of arthrogryposis","volume":"184","author":"Hall JG","year":"1985","journal-title":"Clin Orthop"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250112"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320120404"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999534"},{"key":"e_1_2_1_16_1","first-page":"247","article-title":"Intrinsic versus extrinsically derived deformational defects: A clinical approach","volume":"7","author":"Jones MC","year":"1983","journal-title":"Semin Perinatol"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000144714"},{"key":"e_1_2_1_18_1","first-page":"193","volume-title":"Cytogenetics, Environment and Malformation Syndromes","author":"Mease AD","year":"1976"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1542\/peds.49.3.392","article-title":"Fetal growth and neonatal mortality","volume":"49","author":"Miller HC","year":"1972","journal-title":"Pediatrics"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80577-6"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80664-6"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1542\/peds.67.5.618","article-title":"Short umbilical cord: Its origin and relevance","volume":"67","author":"Miller ME","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.72.6.857"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198202000-00006"},{"key":"e_1_2_1_25_1","first-page":"95","article-title":"The role of the functional matrix in mandibular growth","volume":"38","author":"Moss ML","year":"1968","journal-title":"Angle Orthod"},{"key":"e_1_2_1_26_1","first-page":"33","article-title":"Growth analysis in clinical genetics","volume":"200","author":"Opitz JM","year":"1985","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420420102"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80119-8"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198870070-00014"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553275"},{"key":"e_1_2_1_31_1","first-page":"140","volume-title":"Skeletal Muscle Pathology","author":"Sarnat HB","year":"1982"},{"key":"e_1_2_1_32_1","first-page":"1021","article-title":"Commentary: Redundant skin folds in the infant","volume":"94","author":"Smith DW","year":"1979","journal-title":"Their origin and relevance. 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