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The girl was the firstborn child of consanguineous parents and had trigonocephaly, apparent hypertelorism, upslanted palpebral fissures, strabismus, small nose with broad root, abnormally modeled ears, high palate, short neck with loose skin, polysyndactyly, and prominent clitoris and labia majora. In addition, a complex cardiovascular defect (Eisenmenger disease) was observed. The patient was mentally retarded.<\/jats:p>","DOI":"10.1002\/ajmg.1320400413","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:26:01Z","timestamp":1118550361000},"page":"444-446","source":"Crossref","is-referenced-by-count":18,"title":["Opitz trigonocephaly syndrome"],"prefix":"10.1002","volume":"40","author":[{"given":"Thomas","family":"Haaf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320090209"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370407"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/74.2.206"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370405"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00443223"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320180109"},{"key":"e_1_2_1_8_1","first-page":"485","article-title":"Opitz trigonocephaly syndrome and terminal transverse limb reduction defects","volume":"40","author":"Fryns JP","year":"1985","journal-title":"Helv Paediat Acta"},{"key":"e_1_2_1_9_1","first-page":"191","article-title":"Distal 11q deletion: A specific clinical entity","volume":"42","author":"Fryns JP","year":"1987","journal-title":"Helv Paediat Acta"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.13.1.77"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370404"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1975.02120480062016"},{"key":"e_1_2_1_13_1","volume-title":"Malformation Syndromes","author":"Opitz JM","year":"1969"},{"issue":"2","key":"e_1_2_1_13_2","first-page":"161","author":"National Foundation\u2013March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_14_1","volume-title":"Malformation Syndromes II","author":"Preus M","year":"1975"},{"issue":"2","key":"e_1_2_1_14_2","first-page":"58","author":"National Foundation\u2013March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320230409"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.22.1.39"},{"key":"e_1_2_1_17_1","first-page":"711","article-title":"Familial trigonocephaly associated with short stature and developmental delay","volume":"135","author":"Say B","year":"1981","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_18_1","first-page":"309","article-title":"Terminal deletion of the short arm of chromosome 3, del(3pter\u2192p25): a recognizable syndrome","volume":"42","author":"Schwyzer U","year":"1987","journal-title":"Helv Paediat Acta"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370406"},{"key":"e_1_2_1_20_1","first-page":"10","volume-title":"Das charakteristische Syndrom. 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