{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T21:31:20Z","timestamp":1700170280367},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T00:00:00Z","timestamp":1118016000000},"content-version":"vor","delay-in-days":4922,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1991,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 35\u2010month\u2010old black boy with Hallermann\u2013Streiff syndrome (HSS) was evaluated for anterior hypopituitarism when he presented with ketotic hypoglycemia, microgenitalia, and short stature. Endocrine evaluation showed a low T<jats:sub>4<\/jats:sub> and TSH levels, suggesting hypothalamic hypothyroidism; this was confirmed by TRH stimulation. Metyrapone test confirmed ACTH deficiency as a contributing factor to the ketotic hypoglycemia. A superagonist GnRH test suggested hypothalamic GnRH deficiency. Growth hormone provocative testing conclusively demonstrated complete growth hormone deficiency. MRI investigation of the brain suggested hypopituitarism. Although facial findings were not completely classical of the HSS, we suggest these may be some what altered due to his racial background. We recommend endocrine evaluation of HSS patients with manifestations suggesting hypopituitarism since treatment of this condition will improve the quality of life of these patients.<\/jats:p>","DOI":"10.1002\/ajmg.1320410425","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:31:54Z","timestamp":1118550714000},"page":"503-507","source":"Crossref","is-referenced-by-count":4,"title":["Hallermann\u2010Streiff syndrome with hypopituitarism contributing to growth failure"],"prefix":"10.1002","volume":"41","author":[{"given":"Enik\u00f6 K.","family":"Pivnick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Burstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sid Wilroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jewell C.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"898","article-title":"Vari\u00e9t\u00e9 singuli\u00e8re d'alop\u00e9cie cong\u00e9nitale: Alop\u00e9cie suturale","volume":"4","author":"Aubry M","year":"1993","journal-title":"Ann Dermatol Syphiligr (Paris)"},{"key":"e_1_2_1_3_1","first-page":"987","article-title":"Central serous choroidopathy in the Hallermann\u2010Streiff syndrome","volume":"13","author":"Blair NP","year":"1981","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)81120-2"},{"key":"e_1_2_1_5_1","first-page":"1791","article-title":"Aspects of endocrine function in the Hallermann\u2010Streiff\u2010Fran\u00e7ois syndrome","volume":"31","author":"Cicognani A","year":"1979","journal-title":"Minerva Pediatr"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80076-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1958.00940080862005"},{"key":"e_1_2_1_8_1","first-page":"189","article-title":"Cardiorespiratory disease associated with Hallermann\u2010Streiff syndrome: Analysis of craniofacial morphology by cephalometric roentgenograms","volume":"1","author":"Friede H","year":"1985","journal-title":"J Craniofac Genet Dev Biol (Supp)"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389000500112"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-39-461-377"},{"key":"e_1_2_1_11_1","first-page":"315","article-title":"Vogelgesicht und Cataracta congenita","volume":"113","author":"Hallermann W","year":"1948","journal-title":"Klin Monatsbl Augenhlk"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.40.209.57"},{"key":"e_1_2_1_13_1","first-page":"516","volume-title":"Werner's The Thyroid. 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