{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:01:45Z","timestamp":1695877305143},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,8]],"date-time":"2005-06-08T00:00:00Z","timestamp":1118188800000},"content-version":"vor","delay-in-days":4893,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1992,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nonclassical congenital adrenal hyperplasia (NCCAH) is well recognized among women who seek medical attention for hirsutism. However, the prevalence of this disorder among women self\u2010referred for electrolytic treatment of hirsutism is unknown. We hypothesized that the prevalence of NCCAH among women attending an electrolysis clinic might be high. By measuring the morning salivary 17\u2010hydroxyprogesterone (17\u2010OHP) as a screening test for NCCAH in 46 women in the follicular phase of their menstrual cycle, we identified 12 subjects with a high basal salivary 17\u2010OHP. Eleven agreed to have a 60\u2010minute Cosyntropin\u2010stimulation test, as did an additional 6 of 9 women with normal basal salivary 17\u2010OHP, but with a particularly high hirsutism score. One of the women with high basal salivary 17\u2010OHP had a 60\u2010minute Cosyntropin response, which was diagnostic of NCCAH. She was of the Ashkenazi Jewish decent, a group previously reported to have a high prevalence of NCCAH. A second woman with high salivary 17\u2010OHP had a Cosyntropin\u2010stimulation response consistent with heterozygosity for 21\u2010hydroxylase deficiency. None of the Cosyntropin\u2010stimulation responses in those chosen for a high hirsutism score were diagnostic. Thus, 1 of 46 (2.2%) of the women who entered our study had unrecognized NCCAH, a prevalence only about 2\u2010fold greater than that reported in the general population. Therefore, we recommend that electrolysis clinics advise clients from ethnic groups known to have a high frequency of NCCAH of the advisability of having a formal medical evaluation for NCCAH.<\/jats:p>","DOI":"10.1002\/ajmg.1320420212","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T19:19:33Z","timestamp":1123528773000},"page":"197-200","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of nonclassical congenital adrenal hyperplasia among women self\u2010referred for electrolytic treatment of hirsutism"],"prefix":"10.1002","volume":"42","author":[{"given":"Anthony A.","family":"Killeen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi Q.","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Eklund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina J.","family":"Cairl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Eckfeldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-21-11-1440"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290340"},{"key":"e_1_2_1_4_1","first-page":"67","volume-title":"Molecular Diagnostics in Pathology","author":"Killeen AA","year":"1990"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-2-320"},{"key":"e_1_2_1_6_1","first-page":"1881","volume-title":"The Metabolic Basis of Inherited Disease","author":"New MI","year":"1989"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199009273231301"},{"key":"e_1_2_1_8_1","first-page":"830","article-title":"A segregation and linkage study of classical and nonclassical 21\u2010hydroxylase deficiency","volume":"42","author":"Sherman SL","year":"1988","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_9_1","first-page":"650","article-title":"High frequency of nonclassical steroid 21\u2010hydroxylase deficiency","volume":"37","author":"Speiser PW","year":"1985","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_10_1","first-page":"21","article-title":"Adrenal virilism due to 21\u2010hydroxylase deficiency in the postmenarchial female","volume":"45","author":"Riddick DH","year":"1975","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-65-2-227"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-6-1662"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320420212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320420212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T01:51:39Z","timestamp":1695865899000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320420212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1,15]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,1,15]]}},"alternative-id":["10.1002\/ajmg.1320420212"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320420212","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1,15]]}}}