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Here we suggest that some of the cases previously designated as being multifactorial in origin may be interpreted instead as resulting from a single\u2010gene mutation, by applying a stochastic single\u2010gene model. A variety of models of the pathogenesis of HFM have been described, including the proposal that local embryonic haemorrhage is a causal mechanism. More recently, it has been suggested that an interference in chondrogenesis is primarily responsible for the HFM phenotype. In this paper direct experimental evidence, based on surgical interference of mandibular development in the chick embryo, is applied in favour of the latter concept. In particular, asymmetrical perturbation of Meckel's cartilage has been shown to result in asymmetry of the mandible, and it is proposed that, irrespective of cause, the skeletal pathogenesis of HFM primarily involves the auriculofacial cartilage model.<\/jats:p>","DOI":"10.1002\/ajmg.1320420410","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:39:44Z","timestamp":1118497184000},"page":"461-466","source":"Crossref","is-referenced-by-count":41,"title":["Hemifacial microsomia: Developmental consequence of perturbation of the auriculofacial cartilage model?"],"prefix":"10.1002","volume":"42","author":[{"given":"R. R. J.","family":"Cousley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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