{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T20:41:50Z","timestamp":1698180110438},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":4815,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Associations are statistical clusterings of malformations not known to be polytopic field defects, sequences, or syndromes. The VATER association is a nonrandom association of malformations including vertebral, anal, cardiovascular, tracheoesophageal, genitourinary, and limb defects. The caudal \u201cdysplasia\u201d sequence of lumbosacral vertebral defects, genitourinary abnormalities, and imperforate anus overlaps the VATER association. The cloacal membrane agenesis sequence is a pattern of malformations resulting in the absence of anal, genital, and urinary orifices with associated malformations in surrounding structures. We report on a 37\u2010week gestation liveborn male with oligohydramnios deformations, tetralogy of Fallot, \u201cH\u2010type\u201d tracheoesophageal fistula, duodenal atresia, imperforate anus, urethral atresia, undescended testes, absent right kidney with a small dysplastic left kidney, a \u201ccloacal\u2010like\u201d abnormality of the bladder and distal bowel, and thoracic and lumbar vertebral hypersegmentation. This patient has manifestations of the VATER association, the caudal dysplasia sequence, and the cloacal membrane agenesis sequence. We propose that some of his defects may represent a malformation sequence secondary to excessive embryonic flexion resulting from vertebral hypersegmentation.<\/jats:p>","DOI":"10.1002\/ajmg.1320420603","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:55:27Z","timestamp":1118537727000},"page":"766-770","source":"Crossref","is-referenced-by-count":9,"title":["Vertebral hypersegmentation in a case of the VATER association"],"prefix":"10.1002","volume":"42","author":[{"given":"Eric A.","family":"Wulfsberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri L.","family":"Phillips\u2010Dawkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald L.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.36.186.152"},{"key":"e_1_2_1_3_1","first-page":"96","article-title":"Sirenomelia and VATER association: Possible interrelated disorders with common embryologic pathogenesis","volume":"2","author":"Duncan PA","year":"1988","journal-title":"Dysmorphol Clin Genet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320210104"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250607"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1542\/peds.65.3.508","article-title":"Anomalies of heart, spleen, kidneys, gut and limbs may result from an overdistended neural tube: A hypothesis","volume":"65","author":"Gardner WJ","year":"1980","journal-title":"Pediatrics"},{"key":"e_1_2_1_7_1","first-page":"xviii","volume-title":"Smith's Recognizable Patterns of Human Malformations","author":"Jones KL","year":"1988"},{"key":"e_1_2_1_8_1","first-page":"570","volume-title":"Smith's Recognizable Patterns of Human Malformations","author":"Jones KL","year":"1988"},{"key":"e_1_2_1_9_1","first-page":"584","volume-title":"Smith's Recognizable Patterns of Human Malformations","author":"Jones KL","year":"1988"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1542\/peds.71.5.815","article-title":"A population based study of the VACTERL association: Evidence for its etiologic heterogeneity","volume":"71","author":"Khoury MJ","year":"1983","journal-title":"Pediatrics"},{"key":"e_1_2_1_11_1","first-page":"979","article-title":"Genetics, chance and morphogenesis","volume":"41","author":"Kurnit DM","year":"1987","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250603"},{"key":"e_1_2_1_13_1","first-page":"80","article-title":"Different clusters within the VATER association distinguished through cardiac defects: Possible effects of teratologic timing","volume":"1","author":"Lubinsky M","year":"1987","journal-title":"Dysmorphol Clin Genet"},{"key":"e_1_2_1_14_1","first-page":"373","article-title":"Neural crest defects: A neuroanatomic basis for classification of multiple malformations related to phocomelia","volume":"28","author":"McCredie J","year":"1976","journal-title":"J Neurol Dis"},{"key":"e_1_2_1_15_1","unstructured":"OpitzJM CareyJC LubinskyMS(1984)Studies of human malformation minor anomalies and malformation associations. 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