{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:13:42Z","timestamp":1777342422251,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":4706,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1992,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosome complements were studied in 118 sperm from a man heterozygous for a 15;22 Robertsonian trnaslocation using the human sperm\/hamster oocyte fusion technique. Alternate segregation occurred in most spreads (89.6%) and the proportion of normal (42.6%) and balanced complements (47%) was approximately equal. The frequency of sperm that were unbalanced with respect to the translocation was 10.4% and all categories of unbalanced sperm were observed (\u221215, \u221222, +15, +22). The frequency of chromosome abnormalities unrelated to the translocation was 7.6%. Since the frequencies of both numerical (3.4%) and structural abnormalities (3.4%) were within the normal range of control donors, there was no evidence for an interchromosomal effect. The frequencies of X\u2010chromosome bearing (48%) and Y\u2010chromsome bearing (52%) sperm were not significantly different from 50%. Data on this translocation were compared to the 4 other reports of cytogenetic analysis in sperm of Robertsonian translocation carriers. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320430520","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:49:25Z","timestamp":1118551765000},"page":"855-857","source":"Crossref","is-referenced-by-count":22,"title":["Analysis of sperm chromosome complements from a man heterozygous for a Robertsonian translocation 45,XY,t(15q;22q)"],"prefix":"10.1002","volume":"43","author":[{"given":"Ren\u00e9e H.","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Hildebrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320160206"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970040705"},{"key":"e_1_2_1_4_1","first-page":"766","article-title":"A cytogenetic investigation of the effects of cryopreservation on human sperm","volume":"45","author":"Chernos JE","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_5_1","first-page":"11","article-title":"Etude de la descendance des individus porteuns d'une translocation t(Dq;Dq)","volume":"13","author":"Dutrillaux B","year":"1970","journal-title":"Ann G\u00e9n\u00e9t (Paris)"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130843"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132023"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131876"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00273651"},{"key":"e_1_2_1_10_1","first-page":"461","article-title":"Invited Editorial: Segregation analysis of translocations by the study of human sperm chromosome complements","volume":"44","author":"Martin RH","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00272374"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00276325"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00284905"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132098"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1982.tb00229.x"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320430520","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320430520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T20:07:34Z","timestamp":1698091654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320430520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7,15]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,7,15]]}},"alternative-id":["10.1002\/ajmg.1320430520"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320430520","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7,15]]}}}